Posted by brynb on August 4, 2012, at 2:29:27
In reply to Re: NMDA Antagonists + Synthetic Opioids » brynb, posted by phidippus on August 3, 2012, at 22:41:11
> Tramadol is a weak mu/kappa agonist. ITss a much more powerful NMDA antagonist and really likes to hit those S/N receptors. You probably did ok with Tramadol's SNRI activity on account of its weak opioid effect.
That makes sense...maybe that kind of mitigated the NRI properties? It also really helps leg and arm pain that I get that's not systemic, so basically it must be depression-related and psychosomatic.
>
> What I find funny is people going off on Tramadol as being so causing of dependency. They don't realize how weak of an opiate Tramadol is. The idea of getting hooked on it makes me laugh.
>Fortunately I haven't had any trouble tapering off of it--it's more a psychological thing (I'm really scared my mood's gonna plummet). But so far, so good.
I'm rather annoyed my pdoc is taking me off of it (for now). I never had to raise the dose, never got addicted to it (at least in the compulsive sense), and NEVER wanted to take more than prescribed. And I benefited from all of its effects on various neurotransmitters w/o the unbearable side effects of many other psych drugs.
> Subutex is Bupernorphine with nalexone added. I prefer my Bup straight.
I thought it was just Bup. Isn't it Suboxone that's mixed with Naloxone?
>Be careful with Subutex...As an opioid agonist its about 50 times stronger than morphine.
I knew it was a decent opioid agonist but didn't realize it was that strong! I've used it in the past to help me come off several things (even benzos at one point). I used the 2s & 8s, but at the time, during addiction, it didn't seem like much. However, I've been drug free (not including psych meds!) for a long time now, and my doc would give me a much smaller amount. (And I'm sure it would "feel" much more potent).
The funny thing is, my pdoc is so concerned w/ me getting dependent on both tram & bup, but truthfully, I don't see it as too much different than my dependency on ADs. It's not exactly a picnic coming off SRIs. And I've withdrawn from a lot of drugs, and IMO, benzos and ADs are some of the hardest!
Also, last time I had nitrous oxide at the dentist (say, 4 months ago), I freaked--total dissociation and horrible depression/anxiety for hours after. Isn't it an NMDA too?
-b
poster:brynb
thread:1022575
URL: http://www.dr-bob.org/babble/20120803/msgs/1022696.html