Posted by SLS on March 15, 2013, at 15:12:30
In reply to Re: Anyone else fail trials of the MAOIs? » SLS, posted by Roslynn on March 15, 2013, at 14:17:19
> > > Wellbutrin gave me facial tics
> >
> > Has ADD / ADHD been considered?
> >
> > Have you tried desipramine?
> >
> >
> > - Scott
>
> Hi Scott,
>
> I think ADD/ADHD has been ruled out. Stimulants make me tired, of all things.
>
> I have had short-lived success with desipramine in the past.
>
> Roslynn
Gosh. What haven't you tried?I see that you've been around the block a few times.
Keep trying. I feel that the odds are in your favor that something will work, especially in light of your positive responses to treatment in the past.
I mentioned ADD because of the tics you described.
Have you tried memantine (Namenda)?
I wonder if D-cycloserine, currently marketed as an antibiotic anti-tuberculin, might be a substance worth adding. Like ketamine, it works on the NMDA receptor complex to reduce currents. Unlike ketamine, it acts as a partial agonist of the glycine subunit, and does not produce the adverse cognitive effects of ketamine. There are several other orally-administered compounds in development as antidepressants that work this way, but they might be a few years away from reaching market.
http://www.ncbi.nlm.nih.gov/pubmed/23174090
http://clinicaltrials.gov/show/NCT00408031
I guess you need to develop a core antidepressant treatment around which to build and add other types of drugs as adjuncts. What would be your guesses as to which antidepressants have the most potential to produce any kind of improvement?
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1040142
URL: http://www.dr-bob.org/babble/20130308/msgs/1040401.html