Posted by Roslynn on March 17, 2013, at 14:25:23
In reply to Re: Anyone else fail trials of the MAOIs? » Roslynn, posted by SLS on March 15, 2013, at 15:12:30
Hi Scott,
Thanks for your message.
My doc has been trying to get me off the seroquel and lithium for quite a while but it creates severe panic. So those are still stuck in my cocktail.
Thank you for your mention of different agents such as memantine but I am nowhere near being sophisticated when it comes to investigating or proposing new/different agents to my pdoc. I don't live anywhere like NYC where you might find the cutting-edge doctors. I am too tired to research much on my own other than coming to this board.
My best guess as to a future med would be either something from the TCA class, perhaps in combination. This because I did respond very briefly to desipramine and I got a longer response to the combo of clomipramine and prozac (probably contraindicated but my doc let me stay on it.) It was due to an overlap while I was trying to transition.
Other than that, possible Effexor (yikes) or Pristiq. I may have tried Effexor very briefly, and Pristiq I think I could have done a longer trial.Thank you for listening!
Roslynn
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> Gosh. What haven't you tried?
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> I see that you've been around the block a few times.
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> Keep trying. I feel that the odds are in your favor that something will work, especially in light of your positive responses to treatment in the past.
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> I mentioned ADD because of the tics you described.
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> Have you tried memantine (Namenda)?
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> I wonder if D-cycloserine, currently marketed as an antibiotic anti-tuberculin, might be a substance worth adding. Like ketamine, it works on the NMDA receptor complex to reduce currents. Unlike ketamine, it acts as a partial agonist of the glycine subunit, and does not produce the adverse cognitive effects of ketamine. There are several other orally-administered compounds in development as antidepressants that work this way, but they might be a few years away from reaching market.
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> http://www.ncbi.nlm.nih.gov/pubmed/23174090
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> http://clinicaltrials.gov/show/NCT00408031
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> I guess you need to develop a core antidepressant treatment around which to build and add other types of drugs as adjuncts. What would be your guesses as to which antidepressants have the most potential to produce any kind of improvement?
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>
> - Scott
"You'll remember me when the west wind moves
Upon the fields of barley
You can tell the sun in his jealous sky
When we walked in fields of gold."
poster:Roslynn
thread:1040142
URL: http://www.dr-bob.org/babble/20130308/msgs/1040547.html