Posted by phidippus on February 26, 2014, at 22:41:42
In reply to Re: Advice on which medication is best for my case, posted by kavinsky99 on February 26, 2014, at 19:10:49
>I wouldn't say they're racing thoughts, just repetitive, relentless and extremely attention draining. Everything feels like second-priority compared to them, according to my brain.
You can't distract?
> They're unpleasant in nature, mostly based on memories of bad things that happened and ruminations regarding them.
Therapy is going to help you most with this issue.
> I don't cope. I literally just try to not think.
How's that working out?
>Other activites or "distractions" seem to actually worsen them.
Why do you think that is?
> For depressed, anxious and bipolar people, is dopamine suppression the key-effect for the benefits received from APs?
Well, schizophrenics benfit from the dopamine antagonism and certain seraotonin antagonism. While bipolar folk get the best benefit from seratonin antagonism as well as the dopamine antagonism. But now a days, a lot of the atypicals feature 5ht1a agonism, whicch helps with depression.
> I wish I could try the norepinephrine ones first... I suffer from really bad nerve pain on my spine. Don't know if that worsens anxiety and OCD, though.
You and me both. I've never tried something that boosts norepenephrine.
>By the way, benzos usually make me very agressive and depressed.
this is called a paradoxical effect. happens to me with certain benzos as well - Xanax is the worst. Last time I took it I had full blown ideations of bashing my son's head in.
> What kind of side effects you had it on it?
Some sedation. Sometimes a depressed mood.
> Why is it important to have a serotonergic antidepressant on board?
When you have OCD, their are depletions of serotonin in certain parts of the brain. If you take an AP, those depletions worsen, making symptoms worse. Treating OCD with a serotogenic drug corrects the serotonine imbalance in the brain, easing the symptoms of OCD. Often, dopaminergic transmission is defective in the brains of people with OCD resulting in a surplus of dopamine. That's why APs are also used to treat OCD-the trick being that if you use too much AP, too much serotonin gets antagonized and symptoms worsen. Just enough AP corrects dopamine levels.
>Thought APs usually had serotonergic properties of their own.
They antagonize way more serotonine receptors than they agonize.
>Honestly, therapy retraumatizes me even subconsciouslly.
That's kind of the point of therapy with OCD - ERP (exposure and ritual prevention). You are exposed to the thing that causes you anxiety systematically until it no longer causes you anxiety.
Eric
poster:phidippus
thread:1060760
URL: http://www.dr-bob.org/babble/20140214/msgs/1061420.html