Posted by jrbecker76 on May 9, 2014, at 9:48:36
In reply to Re: Brintellix Trial 10mg. @Eric, Scott, Lamdage22 » LouisianaSportsman, posted by SLS on March 3, 2014, at 19:45:05
> > > Good luck!
> > >
> > >
> > > - Scott
>
>
> > Thanks!
> >
> > Scott, are you on asenapine now?
> >
> > I'll let you know if this Brintellix is worth the Parnate switch or not.
>
> Thanks - big time.
>
> > I let you down on the lurasidone, so be weary of my advice, lol.
>
> Silly!
>
> My reaction to asenapine was very similar to lurasidone. I felt better for a few days, and then began to deteriorate. I felt worse on it than off it. I attribute this to NE alpha-2a receptor antagonism. Both drugs do this. So do mirtazapine and idazoxan. All four of these drugs exacerbate my depression. I can't help but to conclude that NE alpha-2a antagonism is to blame. In the cases of lurasidone and asenapine, I think the 5-HT7 receptor blockade produced the initial improvement, only to be opposed later by the emergence of sufficient NE alpha-2 blockade to disrupt my mood. I think it was a matter of time dependence rather than dosage dependence.
>
> I am very anxious to see how people do on Brintellix. Eric (Phiddipus) has chosen to describe his response to Brintellix using words that I like to hear.
>
>
> - Scott
Hi Scott,Just curious when you had the opportunity to try Idazoxan. Was it in a clinical trial?
I've come to the conclusion that alpha-2 NE activity might also be counterproductive for me. Just my hunch given certain reactions (i.e., irritability, agitation) I've had to drugs that hit that profile (e.g., Mirtazapine, Seroquel). I've wanted to do a trial with Yohimbine just to confirm it, but I think this would be confounded by the fact that Yohimbine has affinity for 5-HT1b as well which would also probably contribute to its deleterious effects.
JB
poster:jrbecker76
thread:1061746
URL: http://www.dr-bob.org/babble/20140419/msgs/1065410.html