Posted by jrbecker76 on May 10, 2014, at 10:42:43
In reply to Re: Brintellix Trial 10mg. @Eric, Scott, Lamdage22 » jrbecker76, posted by SLS on May 9, 2014, at 14:19:08
> Hi JRB.
>
> > Hi Scott,
> >
> > Just curious when you had the opportunity to try Idazoxan. Was it in a clinical trial?
>
> 1992 at the National Institutes of Health - NIMH. It made my depression significantly worse. This is also true of Remeron, Latuda, and Saphris. Latuda was worse than Saphris.
>
> I really went to the NIMH so that I could be treated with clorgyline (irreversible specific MAO-A inhibitor). I hadn't anticipated 12 weeks of idazoxan hell in order to try it.
>
> > I've come to the conclusion that alpha-2 NE activity might also be counterproductive for me. Just my hunch given certain reactions (i.e., irritability, agitation) I've had to drugs that hit that profile (e.g., Mirtazapine, Seroquel). I've wanted to do a trial with Yohimbine just to confirm it, but I think this would be confounded by the fact that Yohimbine has affinity for 5-HT1b as well which would also probably contribute to its deleterious effects.
>
> I didn't know that Seroquel or any of its metabolites were NE alpha-2 antagonists. Science discovers new properties of old drugs all of the time.
>
>
> - ScottInteresting. Yes, in regards to Seroquel, my theory is that the metabolite's binding affinity with alpha-2 in combination with extremely potent NE reuptake inhibition might lead to my adverse reaction to it.
In regards to NE reuptake, I know we also share caution that front as well. I fare very poorly on Reboxetine (most do of course) as well as Milnacipran. I do, however, fare well on lower doses of Effexor and Cymbalta, the former of which I take currently.
JB
poster:jrbecker76
thread:1061746
URL: http://www.dr-bob.org/babble/20140419/msgs/1065446.html