Posted by hello321 on October 8, 2015, at 16:21:53
In reply to Re: Shooters and Psychiatry » hello321, posted by SLS on October 7, 2015, at 0:54:17
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> What are your reasons for focusing on 5-HTc receptors?
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> - ScottBasically I've been pretty certain my fundamental problem is with a deficit in dopamine. Severe anhedonia seems to be my core symptom. But I haven't been responding at all, good or bad, to the typical dopamine increasing meds. nor have I gotten any effect from Haldol. Tho I haven't been responding to the many other psych meds I've tried the past few years either. You that pretty well described my thoughts on why I've not responded to meds in a post you wrote: "Brains such a these are more apt to respond to current treatments than one that have more profound abnormalities in function or morphology." In the thread about placebo response.But theres a lot to my situation that's a bit complicated to describe.
But before I tried cyproheptadine, I had tried a few atypical antipsychotics that antagonize the 2a receptor, along with their other effects, and receiveed no benefit. These meds were also antagonists at the 2c receptor. But when I tried cyproheptadine, I just benefited hugely. And when I read into its effects and how it might have helped me, I read the 2c receptor has "constitutive" control over dopamine release in the brain. Basically that receptor just existing puts a damper on dopamine. And it requires an inverse agonist to fully inhibit its constitutive activity. So then dopamine is more free to be released in response to pleasure. Rather than an increase of dopamine being forced by something like adderall.
After writing this I think I do recall the 2a receptor also having contitutive control over dopamine. And I don't think I've ever tried a 2a inverse agonist. not sure if I've looked specifically into 2a agonists in the past, or not, so maybe would be a good idea for me to look into.
poster:hello321
thread:1083163
URL: http://www.dr-bob.org/babble/20150929/msgs/1083323.html