Posted by SLS on March 11, 2018, at 8:31:25
In reply to Re: Best meds for 'I don't care anymore' sydrome, posted by Lamdage22 on March 11, 2018, at 6:32:58
> I wouldnt place my bet on medication only with this issue. There is no drugs approved for "i dont care"...
With some cases of depression, "loss of interest" is the prominent symptom. I am more disinterested and lacking in motivation than I am sad. I found that Nardil - when it worked for me - was the best drug for these symptoms. Parnate is not as effective for me. I found Effexor to be pretty good. For some people, the right SSRI can produce full remission. However, amotivation and apathy can be side effects. I really don't see this with the SNRIs. Of the tricyclics, I would suggest nortriptyline or imipramine as alternatives. Imipramine carries with it more pronounced anticholinergic side effects, so nortriptyline is the drug I would try first. If you want, you can take a test that shows your levels of C-reactive protein (CRP). This is a biomarker for inflammation, and can predict which antidedpressants you have a better chance of responding to. High levels predict a better response to nortriptyline. Low levels predict a better response to Lexapro. I don't know if this extends to other serotonin reuptake inhibitors, though.
As Lamdage suggests, your lack of interested could be due to psychosocial factors rather than biological ones. It might be worth discussing this with a psychiatrist or psychologist if drugs don't help.
How is your energy level? Wellbutrin can help with this. Even if it does, it may not help with lack of interest. However, Wellbutrin can work well when combined with a SSRI or SNRI to hit both energy and interest deficits.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1097273
URL: http://www.dr-bob.org/babble/20180212/msgs/1097283.html