Posted by undopaminergic on May 3, 2020, at 3:52:53
In reply to Re: Starting Cocaine XR next week » rjlockhart37, posted by linkadge on May 1, 2020, at 18:00:41
> Many of the cardiovascular issues are likely caused by a large surge in norepinephrine via reuptake inhibition and/or release. Some of it could be related to sodium channel blockade at high doses.
>Probably not -- I read that all the -caine local anaesthetics, except for cocaine, induce vasodilation.
I think it's the noradrenaline. From what I read, it often appears that cocaine is a particularly strong noradrenaline reuptake inhibitor, in comparison with eg. methylphenidate. Maybe the dose-response curve does *not* flatten at higher doses.
-undopaminergic
poster:undopaminergic
thread:1109688
URL: http://www.dr-bob.org/babble/20200303/msgs/1109948.html