Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Akathisia, meds , Pseudo-Parkinson and help pls.:( » jay2112

Posted by PCB on October 18, 2020, at 14:27:49

In reply to Re: Akathisia, meds , Pseudo-Parkinson and help pls.:( » linkadge, posted by jay2112 on October 17, 2020, at 17:21:47

>Interesting thing about Effexor...he said there is a bit of a >controversy on it's effects on norepinephrine, that it is a fair >bit weaker on norepinephrine than thought...even with the >dose escalation.(I'd have to look up the references.)

There is no controversy. Effexor and most of the SNRIs are very weak norepinephrine reuptake inhibitors. Here are the ratios of serotonin to norepinephrine reuptake inhibition:

Effexor/Venlafaxine 30:1 (serotonin:norepinephrine, higher number means more inhibition/stronger)
Duloxetine 10:1
Desvenlafaxine 10:1
Levomilnacipran 1:1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008300/#!po=1.61290
https://en.m.wikipedia.org/wiki/Clomipramine#Serotonergic_activity (under pharmacodynamics)

So really most of the SNRIs are just SSRIs with the exception of Levomilnacipran. Although some people do get blood pressure increases on a SNRIs due to the norepinephrine effect, so maybe in vitro the norepinephrine effect is significant. You could add Wellbutrin to a SSRI if you wanted more balanced reuptake of serotonin to norepinephrine.

But linkage would know better than I. He is the master! Sorry if you know all this already.

PCB


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:PCB thread:1112287
URL: http://www.dr-bob.org/babble/20200711/msgs/1112308.html