Posted by raybakes on November 30, 2004, at 6:59:49
In reply to Re: dopamine autoreceptor problem » linkadge, posted by KaraS on November 11, 2004, at 15:16:38
Hi Kara,
Have been taking hawthorn for the last couple of days and get a brain effect similar to when I eat chocolate or have DLPA - I notice it's a phosphodiesterase inhibitor like chocolate too. Phosphodiesterase inhibition should raise Cyclic AMP - would that be good or bad for you?
"autoreceptor regulation of tyrosine hydroxylase must occur through a decrease in cyclic AMP levels."
http://molpharm.aspetjournals.org/cgi/content/abstract/29/6/561
Uncoupling of tyrosine hydroxylase sounds like the metabolic pathway has been disconnected - low biopterin has been mentioned in conection with uncoupling - and folate has been mentioned in studies to resist uncoupling and biopterin degradation.
When biopterin becomes 'uncoupled' from tyrosine hydroxylase, it can produce free radicals such as hydrogen peroxide.
Ray
poster:raybakes
thread:413185
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/422220.html