Posted by KaraS on December 1, 2004, at 22:39:24
In reply to Re: dopamine autoreceptor problem » KaraS, posted by raybakes on November 30, 2004, at 6:59:49
> Hi Kara,
>
> Have been taking hawthorn for the last couple of days and get a brain effect similar to when I eat chocolate or have DLPA - I notice it's a phosphodiesterase inhibitor like chocolate too. Phosphodiesterase inhibition should raise Cyclic AMP - would that be good or bad for you?
>> "autoreceptor regulation of tyrosine hydroxylase must occur through a decrease in cyclic AMP levels."
>
> http://molpharm.aspetjournals.org/cgi/content/abstract/29/6/561
>
> Uncoupling of tyrosine hydroxylase sounds like the metabolic pathway has been disconnected - low biopterin has been mentioned in conection with uncoupling - and folate has been mentioned in studies to resist uncoupling and biopterin degradation.
>
> When biopterin becomes 'uncoupled' from tyrosine hydroxylase, it can produce free radicals such as hydrogen peroxide.
>
> Ray
>Dunno if hawthorne would be good for me or not. From the article you attached it seems that Cyclic AMP activates the tyroxine hydroxylase (which I'm assuming helps to create more dopamine). In the long run that's good I think because you want to flood the synapses with dopamine to force downregulation. The article is too far over my head to say for sure though.
Thanks for thinking of me. If you find out anything more about it, please let me know.
Kara
poster:KaraS
thread:413185
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/423172.html