Posted by KaraS on December 9, 2004, at 16:11:22
In reply to Re: dopamine autoreceptor problem » KaraS, posted by raybakes on December 6, 2004, at 3:44:15
> >
> > Is there no end to the things that can disrupt dopamine production or transmission? It's overwhelming (and I'm sure we've barely touched on all of the possible factors involved). I must sound like a broken record on this topic but I'm tired of trying to figure it all out. Right now I just want to take a pill and make the problem go away!
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> It's so tough all this stuff - as much as i'd like one thing to be available, I'm afraid it's many things, but they do interconnect and paint a broader picture I feel - for me, it's more of an art than a science.
That's great because you enjoy it. I was enjoying it (though I didn't get to your level of scientific understanding) but now I just want some results. Then maybe later I can fine tune things and enjoy the research.
> > There's been some interesting debate about the validity of Glenmullen and Breggin's books on the main board. I'm a bit skeptical of some of their work. The SSRIs inhibiting dopamine is dead on though. Some people seem able to take SSRIs indefinitely without this result for some reason but others of us aren't so lucky. I think that years of SSRI usage may have contributed to my condition now. I strongly suspect that these meds had that negative affect while I was taking them. Now that I am no longer taking them I don't know if they are still a factor in my condition. Unfortunately I can't go back and see if I would still be this anergic had I never taken an SSRI so I will never know for certain how much of a long-term inpact they have had.
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> Looked up a thread on glenmullen - found the arguements quite polarised which was not what I got from the book. I felt he was taking a broad view of all factors, not saying anything was always 'this way' or always 'that way'.I wonder if those taking part in that discussion had read the whole book... I'm glad that it's a more balanced approach though.
> > I hadn't heard of SSRIs reducing female hormones. That wouldn't surprise me either. I remember that when I would start on an SSRI or go off of one, I would have disruptions in my menstrual cycle. I told my pdoc but she said there's no relationship. I told her I didn't believe that because my body was telling me otherwise and that I thought that in time this would come out. (However, some temporary disruptions in my cycle doesn't necessarily mean that they lowered the hormone levels significantly and over the long-term.)
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> Glenmullen talks about the dopamine/serotonin antagonism - dopamine is needed to inhibit prolactin - prolactin when high inhibits hormone prodcution ...think also serotonin has a direct effect on pituitary rhythms and cycles, so wonder if raising serotonin might disturb a woman's delicate time clock?
It definitely did so for me when I'd change dosages but I would always reajust when stablized at a particular dose.
> Ray
poster:KaraS
thread:413185
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/426816.html