Posted by barbaracat on August 14, 2005, at 14:58:34
In reply to Re: The link for DMT cures depression, posted by linkadge on August 14, 2005, at 5:03:47
Interesting article and website. Somewhat off topic, but have you ever looked into the mechanics of transdermal application of meds? I use transdermal creams for hormones and find them more effective than oral. I prefer anything that bypasses the liver. I also have GI absorption issues and would prefer to just inject or rub on my meds whenever I can.
So, I experiment with benign substances, i.e., pain meds that usually rip up my stomach if I take them orally, using DMSO and PhloGel transport mediums. Some results are better than others, probably depending on how soluble the product is as well as other bioassimlation factors I know nothing about.
But I never considered using transdermal delivery for any of my mood meds. I wouldn't want to experiment - too much at stake. Your post got me wondering about how an alternate transport method would affect receptor affinity? Also wondering if the cytochrome P450 isoenzyme metabolites of the drug are really doing the work? In which case the liver's first pass would be necessary and a transdermal delivery would be ineffective - or worse.
Musing, just musing, but these are the kinds of things that keep me up at night. I think I need to take some pharmacology courses.- Barbara
unny because the way that SSRi's increase serotonin is different from how lithium increases serotonin.
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> Lithium actually has a strong serotogenic effect, but it interacts with a few serotonin receptors ie 5-ht2a/c so that PKC is not activated.
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> Serotonin is calming at certain receptors, and upping and other receptors. So to say that a bipolar doesn't need serotonin may or may not be true.
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> Lithium interacts with the 5-ht1b receptor which affects GSK-3b signaling. GSK-3b seems to have a strong effect in regulating the circadian rhythm. A link below.
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> http://www.news-medical.net/?id=11642
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> Actually some people treat their mood disorders solely thought manipulation of sleep. Proponents say its effective and has less burdonsome side effects than conventional treatments.
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> Linkadge
poster:barbaracat
thread:536972
URL: http://www.dr-bob.org/babble/alter/20050812/msgs/541578.html