Posted by Tomatheus on November 25, 2006, at 15:44:38
Does anyone here know of any natural COMT inhibitors other than green tea and quercetin?
Green tea tends to make me feel sleepy, which I suspect may be due to the fact that it contains l-theanine. Of course, the fact that green tea tends to make me feel sleepy could be due to some mechanism that's unrelated to the effects of l-theanine or a combination of mechanisms. But whatever it is in green tea that causes me to feel sleepy, I don't think that it's the chemical that inhibits COMT; I suspect that the sleepiness-inducing effect is probably counteracting the effect that I would get from COMT inhibition.
I tried taking some quercetin yesterday (1800 mg worth), and it didn't seem to have much of an effect on me whatsoever. I suspect that this may be due to the possibility that the form of quercetin that I took may not be absorbed into the bloodstream as readily as isoquercitrin (quercetin-3-0-glucoside), which is supposedly the most bio-available form of quercetin. But there could be other explanations. Maybe I just haven't given the quercetin enough of a chance yet.
So, obviously green tea and quercetin and two options as far as natural COMT inhibition goes. But are there any others?
Tomatheus
poster:Tomatheus
thread:707161
URL: http://www.dr-bob.org/babble/alter/20061118/msgs/707161.html