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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by tensor on September 1, 2009, at 6:38:55
What are your experiences with these as augmentors in treating depression? Is one of them to prefer?
/Mattias
Posted by SLS on September 1, 2009, at 6:54:47
In reply to Buspirone vs Pindolol, posted by tensor on September 1, 2009, at 6:38:55
> What are your experiences with these as augmentors in treating depression? Is one of them to prefer?
>
> /Mattias
Buspirone has more potential to be effective as an augmenter of antidpressants. I guess you already know that buspirone and pindolol do opposite things at 5-HT1a receptors. Pindolol has been reported to speed-up the response to SRI drugs, but does not increase the response rate. Buspirone does. You need to take into consideration that buspirone has a major metabolite that acts as a NE alpha2 antagonist, a property shared with mirtazapine (Remeron). You get two drugs in one with buspirone.
- Scott
Posted by SLS on September 1, 2009, at 10:53:41
In reply to Re: Buspirone vs Pindolol » tensor, posted by SLS on September 1, 2009, at 6:54:47
> > What are your experiences with these as augmentors in treating depression? Is one of them to prefer?
> >
> > /Mattias
>
>
> Buspirone has more potential to be effective as an augmenter of antidpressants. I guess you already know that buspirone and pindolol do opposite things at 5-HT1a receptors. Pindolol has been reported to speed-up the response to SRI drugs, but does not increase the response rate. Buspirone does. You need to take into consideration that buspirone has a major metabolite that acts as a NE alpha2 antagonist, a property shared with mirtazapine (Remeron). You get two drugs in one with buspirone.It really is a crime that gepirone was not approved. It acts like buspirone, only without the dopamine receptor blockade.
- Scott
Posted by tensor on September 1, 2009, at 12:26:51
In reply to Re: Buspirone vs Pindolol, posted by SLS on September 1, 2009, at 10:53:41
Posted by Brainbeard on September 1, 2009, at 15:13:55
In reply to Buspirone vs Pindolol, posted by tensor on September 1, 2009, at 6:38:55
> What are your experiences with these as augmentors in treating depression? Is one of them to prefer?
>
> /MattiasI agree with buspirone being the most likely med to be an AD's little helper.
There is one study that showed rapid onset of antidepressant action for buspirone and pindolol TOGETHER. I tried adding pindolol to my buspirone (and my sertraline, and my ziprasidone) a while ago, but it made my blood pressure sink so low that I felt completely out of it for a few days. Talking about having two drugs in one..
This is the end of the thread.
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