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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by rjlockhart37 on December 29, 2013, at 21:10:44
there is a TON of medications in the Thorazine class....that are there, but there unused, there old, but i just browsed through them on wikipedia and i mean why do they even have these because there's alot of them and there not used that much....
i got this directly from wikipedia....its the first generation nueroleptics
Butyrophenones[edit]
Main article: Butyrophenones
Benperidol (Anguil, Benguil, Frenactil, Glianimon)
Bromperidol (Bromodol, Impromen)
Droperidol (Droleptan, Inapsine)
Haloperidol (Haldol, Serenace)
Moperone (Luvatren (discontinued))
Pipamperone (Dipiperon, Piperonil (discontinued))
Timiperone (Celmanil, Tolopelon)
Diphenylbutylpiperidine[edit]
Fluspirilene (Imap)
Penfluridol (Semap)
Pimozide (Orap)
Phenothiazines[edit]
Main article: Phenothiazines
Acepromazine (Plegicil) although it is mostly used in veterinary medicine.
Chlorpromazine (Largactil, Thorazine (discontinued))
Cyamemazine (Tercian)
Dixyrazine (Esucos)
Fluphenazine (Modecate, Permitil (discontinued), Prolixin (discontinued)) Available in decanoate (long-acting) form
Levomepromazine (Levinan, Levoprome (discontinued), Nozinan)
Mesoridazine (Lidanil, Serentil (discontinued))
Perazine (Peragal, Perazin, Pernazinum, Taxilan)
Pericyazine (Neulactil, Neuleptil)
Perphenazine (Trilafon)
Pipotiazine (Lonseren, Piportil)
Prochlorperazine (Compazine)
Promazine (Prozine, Sparine (discontinued))
Promethazine (Avomine, Phenergan)
Prothipendyl (Dominal)
Thioproperazine (Majeptil) (only English-speaking country it is available in is Canada)
Thioridazine (Aldazine (discontinued), Mellaril (discontinued), Melleril (discontinued))
Trifluoperazine (Stelazine)
Triflupromazine (Vesprin (discontinued))
Thioxanthenes[edit]
Main article: Thioxanthenes
Chlorprothixene (Cloxan, Taractan, Truxal)
Clopenthixol (Sordinol)
Flupentixol (Depixol, Fluanxol)
Tiotixene (Navane, Thixit)
Zuclopenthixol (Acuphase, Cisordinol, Clopixol)
Others[edit]
Clotiapine (Entumine, Etomine, Etumine)
Loxapine (Adasuve, Loxitane)
Prothipendyl (Dominal)why would they have all of this, tons of it, and not use it much anymore....
Posted by Jeroen on December 30, 2013, at 10:07:21
In reply to old unused antipsychotics, posted by rjlockhart37 on December 29, 2013, at 21:10:44
from this board, oh they are still used : )
Posted by Jay_Original1 on December 30, 2013, at 10:16:51
In reply to old unused antipsychotics, posted by rjlockhart37 on December 29, 2013, at 21:10:44
I think the reason so many of these are ignored, is because of the profit-making factor of prescribing the newer atypical ap's. I have tried a few of these older ones, in particular Nozinan and Haldol, and they seemed to not quite work as well as the newer ap's. But, I don't think I was on them long enough, and at high enough of a dose, to really judge them. I think they might be best say in combination with newer meds.
Jay
Posted by ed_uk2010 on December 30, 2013, at 13:43:04
In reply to old unused antipsychotics, posted by rjlockhart37 on December 29, 2013, at 21:10:44
>there is a TON of medications in the Thorazine class....that are there, but there unused, there old, but i just browsed through them on wikipedia and i mean why do they even have these because there's alot of them and there not used that much....
It depends on the country, but not all of these drugs are still sold.
In England, the most widely used 1st generation antipsychotics in tablet form are haloperidol and zuclopenthixol, occasionally chlorpromazine.
1st generation antipsychotics are still widely used as depot injections every 2-4 weeks. The most popular here is zuclopenthixol (Clopixol), followed by flupenthixol (Depixol). Haloperidol (Haldol), fluphenazine (Modecate) and pipothiazine (Piportil) are used somewhat less often. Few newer drugs are available as long-acting depot injections, and the ones which are often don't work any better than Clopixol.
So, there's not a massive range of drugs actually in use... in reality.
Posted by Christ_empowered on December 30, 2013, at 17:14:58
In reply to Re: old unused antipsychotics » rjlockhart37, posted by ed_uk2010 on December 30, 2013, at 13:43:04
I'm weirdly OCD. My shrink was recommending amoxapine, which I vaguely remembered having neuroleptic qualities, so I declined.
Anyway, I read (thanks, wiki) that its related to loxapine. What's with loxapine? Is it atypical? It seems like it'd be ideal if you're on a budget or on a nationalized health-type situation, to contain costs.
Just a random Q.
Posted by Christ_empowered on December 30, 2013, at 17:24:27
In reply to old unused antipsychotics, posted by rjlockhart37 on December 29, 2013, at 21:10:44
I think a lot of those are only used in certain countries, in veterinary medicine, ER situations, or not at all. I mean, there's only so many schizophrenic, bipolar, schizoaffective, agitated, psychotically depressed people, right? And most of us are on an atypical, at least in the US....
....I have heard good things about perphenazine. The CATIE study or whatever rated it just about as good as zyprexa. I don't know if that's so much an endorsement of perphenazine as it is a sign that our "miracle meds" in use today really aren't so miraculous :-(
Posted by Brot on December 30, 2013, at 18:23:37
In reply to old unused antipsychotics, posted by rjlockhart37 on December 29, 2013, at 21:10:44
..." Prothipendyl (Dominal) "...
thats still used as a sleep agent here. not really effective for shizophrenia or psychosis. i use it when i cant sleep and everything else fails...
Posted by linkadge on December 30, 2013, at 20:16:17
In reply to Re: old unused antipsychotics, posted by Brot on December 30, 2013, at 18:23:37
Some of the "typicals" are actually atypical. Perphenazine, for instance, actually has high affinity for serotonin 5-ht2a receptors (a quality deemed "atypical").
Posted by baseball55 on December 30, 2013, at 20:54:13
In reply to Re: old unused antipsychotics, posted by linkadge on December 30, 2013, at 20:16:17
My p-doc told me that perphenazine is the fourth most widely prescribed AP in the US.
Posted by ed_uk2010 on January 5, 2014, at 14:09:22
In reply to ed_uk...loxapine?, posted by Christ_empowered on December 30, 2013, at 17:14:58
> I'm weirdly OCD. My shrink was recommending amoxapine, which I vaguely remembered having neuroleptic qualities, so I declined.
>
> Anyway, I read (thanks, wiki) that its related to loxapine. What's with loxapine?They are related, true. I wouldn't say loxapine is atypical, but it may cause less EPS than other older antipsychotics. To be honest, both drugs were discontinued here many years ago, so I have no real experience with either. I believe amoxapine was briefly used for psychotic depression, but then standard prescribing of an AD + an AP once again became the norm.
Posted by ed_uk2010 on January 5, 2014, at 14:11:37
In reply to Re: old unused antipsychotics, posted by linkadge on December 30, 2013, at 20:16:17
> Some of the "typicals" are actually atypical. Perphenazine, for instance, actually has high affinity for serotonin 5-ht2a receptors (a quality deemed "atypical").
Most phenothiazines block 5-HT2a receptors, but are generally more potent at D2 receptors. Atypicals tend to be the other way around. In contrast to phenothiazines, haloperidol is not active at serotonin receptors.
This is the end of the thread.
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