![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 46. This is the beginning of the thread.
Posted by Dr. Bob on August 14, 2004, at 13:20:16
In reply to Selegiline + Phenylalanine, posted by nemesis on August 14, 2004, at 1:42:44
Posted by nemesis on August 14, 2004, at 1:42:44
> I was first diagnosed with major depression 13 years ago, and have had some form of depression endlessly since (and likely prior, too). I've never been able to tolerate the side effects of pure SSRIs (headache, foggy head, feeling drugged and "on another planet", sexual dysfunction, etc.) for long. The SSNRI Effexor took me from major depression, to completely flat and apathetic, and abandoned me there. I couldn't feel any emotion at all. I've taken Wellbutrin for several different courses and always tolerated it well (only side effect, increases my pre-existing anxiety), but found it to lift mood only very slightly. The only TCA I have tried is Pamelor, which markedly and surprisingly helped my anxiety, and made a mild to moderate dent in my depression, but the side effects piled up over time (weight gain, tiredness, dry mouth, dry skin, constipation, hemorrhoids from constipation in spite of fiber supplements), with the side effects counteracting my gains in getting less depressed. I also tried SAM-E (did nothing except give me a headache), and St. John's wort (did it help mildly sometimes? I'm still not sure).
>
> My best response, on a response to side effect ratio has still been to Wellbutrin, but it never gave me nearly enough of a kick; it was like one bite of an appetizer, with no more food to follow. I read that it somewhat inhibits dopamine reuptake, but then cripples itself by reducing the amount of dopamine your body produces. "Stronger" dopaminergic drugs are illegal, have been removed from the market (e.g., Survector), and/or are potentially addictive and not generally prescribed for depression anymore (e.g., Dexadrine). I read that old-school MAOI Parnate reputedly has a dopaminergic effect, too, but within a smorgasboard of effects and side effects.
>
> Suspecting that, for me, I needed to elevate dopamine levels moreso than serotonin levels, I did a ton of research and somehow stumbled across information on a couple of studies done on a combination of selegiline (Eldepryl) and phenylalanine. The studies, although not placebo-controlled, appeared to show rapid and dramatic results. Other sources attributed this to a dopaminergic effect coming from accumulation of the "chocolate amphetamine", phenylethylamine (PEA). The phenylalanine breaks down in part into PEA, and the selegiline keeps the PEA from dissipating too quickly to have an effect.
>
> Tired of seeing HMO doctors who were always just pushing the next SSRI, or putting me back on Wellbutrin, I located a highly regarded private practice psychopharmacologist, and paid out of pocket to see him. At first he didn't put much stock in my thought of wanting to try selegiline + phenylalanine. He said selegiline isn't an effective antidepressant until you take enough that it becomes a nonselective MAOI similar to Parnate or Nardil. I didn't want to argue on my first visit, that the primary effect was purportedly coming from the phenylalanine (creating PEA) and that selegiline's "low-dose" role was to keep the PEA from metabolizing too quickly.
>
> Over eight months or so, he eventually became open to letting me try the selegiline + phenylalanine combo. He prescribed 10 mg selegiline + 500 mg DL-phenylalanine just yesterday. While it's far too soon to come to any conclusions, I have to say I'm nothing short of amazed less than 12 hours into this. I "felt something" within three to four hours of taking my first selegiline + phenylalanine dose. My energy level, sense of balance, clarity, and focus, are already up, and my mood is noticably elevated. (The only similar experience I can relate, is the amazing "relief" I felt the first time I ever took a Xanax for anxiety.) It will be interesting to see how this progresses. Right now I'm just thrilled after 13 years of unsuccessfully fighting depression, that anything could have a positive effect this quickly.
Posted by joebob on August 19, 2004, at 12:31:51
In reply to Selegiline + Phenylalanine « nemesis, posted by Dr. Bob on August 14, 2004, at 13:20:16
Posted by sfy on September 15, 2004, at 18:33:44
In reply to Selegiline Phenylalanine, posted by nemesis on August 14, 2004, at 1:42:44
Just wondering how the selegiline and DLPA combo is working for you? (or anyone else who might be taking it, Kara?)
Posted by nemesis on September 15, 2004, at 18:33:45
In reply to Re: Selegiline Phenylalanine nemesis, posted by sfy on September 14, 2004, at 16:15:21
After over 12 years of constant depression in various forms, that never responded very well to anything, this has turned out to be the holy grail for me. My psychiatrist saw me within two weeks of my starting on it and he said I looked the best he has ever seen me. I have a full range of emotions on this combo (that's a good thing), and on most days I feel better than I can ever remember previously in my life.
I have stabilized at:
1. 500 mg/day DLPA upon awaking, 30 mins. before food, taken along with 50 mg P-5-P (active form of Vitamin B-6, which helps amino acid absorption).
2. 10 mg/day selegiline hydrochloride right after breakfast.I had increased anxiety and insomnia the first week, but that's gone now and there's really no other side effect. It's clean, and it works fast and well.
D-phenylalanine converts to PEA, while L-phenylalanine converts to PEA and tyrosine, which in turn converts to noradrenaline and dopamine. PEA is an endogenous amphetamine-like compound found in lower levels in many depressed people and higher levels in people who are in love. It boosts mood quickly like amphetamine, but without tolerance. The problem is its amazingly short half life (less than half a minute) - but the selegiline solves that by blocking PEA degradation.
Let me know if you have any questions. I have researched this a lot - and it's really working for me.
> Just wondering how the selegiline and DLPA combo is working for you? (or anyone else who might be taking it, Kara?)
>
Posted by sfy on September 15, 2004, at 18:33:45
In reply to Re: Selegiline Phenylalanine nemesis, posted by nemesis on September 14, 2004, at 21:40:10
> After over 12 years of constant depression in various forms, that never responded very well to anything, this has turned out to be the holy grail for me. My psychiatrist saw me within two weeks of my starting on it and he said I looked the best he has ever seen me. I have a full range of emotions on this combo (that's a good thing), and on most days I feel better than I can ever remember previously in my life.
>
> I have stabilized at:
> 1. 500 mg/day DLPA upon awaking, 30 mins. before food, taken along with 50 mg P-5-P (active form of Vitamin B-6, which helps amino acid absorption).
> 2. 10 mg/day selegiline hydrochloride right after breakfast.
>
> I had increased anxiety and insomnia the first week, but that's gone now and there's really no other side effect. It's clean, and it works fast and well.
>
> D-phenylalanine converts to PEA, while L-phenylalanine converts to PEA and tyrosine, which in turn converts to noradrenaline and dopamine. PEA is an endogenous amphetamine-like compound found in lower levels in many depressed people and higher levels in people who are in love. It boosts mood quickly like amphetamine, but without tolerance. The problem is its amazingly short half life (less than half a minute) - but the selegiline solves that by blocking PEA degradation.
>
> Let me know if you have any questions. I have researched this a lot - and it's really working for me.
Thanks - I'm starting on 5 mg. Selegiline plus DLPA next week (I've got to wait for mirtazapine to wash out). I'm hoping it will help my dysthymia/anhedonia/lack of motivation. I figured I'd give it a shot before having to deal with Parnate.How important is it to have the P-5-P instead of just the usual B6?
Posted by nemesis on September 15, 2004, at 18:33:45
In reply to Re: Selegiline Phenylalanine nemesis, posted by sfy on September 14, 2004, at 22:04:17
Happy to help however I can. You may need to experiment with 5 mg vs. 10 mg of selegiline, and with various levels of DLPA. It took me almost a month to figure out the optimal combo for me. Early on, I took more DLPA (often 1000 mg instead of 500 mg), but over time found out that for me 500 mg is sufficient (and also that 500 mg DLPA 10 mg selegiline seems to lead to less anxiety for me than 1000 mg DLPA 5 mg selegiline). One day early on I took 2000 mg DLPA over the course of a day and felt like a hamster going in an exercise circle. Many months ago I tried L-phenylalanine (not DLPA) by itself without selegiline and got only brief mood spikes (which makes sense now that I know the amazingly short half life of PEA when selegiline is not present).
Re: the B-6, there's not exactly a great body of literature on that (at least not that I've been able to find). But what I have seen indicates that the more commonly available inactive form of B-6 is not absorbed as well as the active form (P-5-P), and when the inactive form is taken singularly (i.e., without a B-complex) at doses of as low as 200 mg/day for a few months it can lead to a (usually) reversible numbness in the limbs, in theory because what's not converted into P-5-P from the inactive form gets stored in your liver and accumulates there. So I decided on the P-5-P. Not as any kind of endorsement, but just as a note of convenience . . . Solgar manfactures both DLPA and P-5-P and you can get both at Whole Foods (if there's one near you and they stock them, as they do in my area), or online at House of Nutrition, which carries the entire Solgar line.
Regarding lack of energy / anhedonia / lack of motivation . . . this may very well solve that for you. I was dysthymic for over 12 years (with a number of major depressions to boot) and I have found this to be amazingly energizing. I can't say I always wake up raring to go, but by the time I'm drving to the office, the DLPA selegiline combo has really kicked in and I feel absoulutely great. I feel like a normal, happy human being now. Never thought I'd be saying that!
I am mystified by why this is "alternative" . . . to me it should be first line therapy given the lack of side effects and the fast onset of action (within hours to a few days, instead of six weeks if at all).
One other thing I'd like to share. In the month I've been taking DLPA selegiline, I have had two nights where I experienced some sadness. In both cases, it was completely gone in the morning. The first time it happened, I was scared that the combo might be losing its efficacy. Not so. I just have a full range of emotions -- there's no flatness. Now I trust it (which was hard to do at first, after 12 years of largely useless drugs) so the second time I felt sad, I just accepted it as normal for anyone occasionally. It's not depression, because it's not sustained. My depression is gone.
> Thanks - I'm starting on 5 mg. Selegiline plus DLPA next week (I've got to wait for mirtazapine to wash out). I'm hoping it will help my dysthymia/anhedonia/lack of motivation. I figured I'd give it a shot before having to deal with Parnate.
>
> How important is it to have the P-5-P instead of just the usual B6?
Posted by karaS on September 15, 2004, at 18:33:47
In reply to Re: Selegiline Phenylalanine nemesis, posted by nemesis on September 14, 2004, at 21:40:10
> After over 12 years of constant depression in various forms, that never responded very well to anything, this has turned out to be the holy grail for me. My psychiatrist saw me within two weeks of my starting on it and he said I looked the best he has ever seen me. I have a full range of emotions on this combo (that's a good thing), and on most days I feel better than I can ever remember previously in my life.
>
> I have stabilized at:
> 1. 500 mg/day DLPA upon awaking, 30 mins. before food, taken along with 50 mg P-5-P (active form of Vitamin B-6, which helps amino acid absorption).
> 2. 10 mg/day selegiline hydrochloride right after breakfast.
>
> I had increased anxiety and insomnia the first week, but that's gone now and there's really no other side effect. It's clean, and it works fast and well.
>
> D-phenylalanine converts to PEA, while L-phenylalanine converts to PEA and tyrosine, which in turn converts to noradrenaline and dopamine. PEA is an endogenous amphetamine-like compound found in lower levels in many depressed people and higher levels in people who are in love. It boosts mood quickly like amphetamine, but without tolerance. The problem is its amazingly short half life (less than half a minute) - but the selegiline solves that by blocking PEA degradation.
>
> Let me know if you have any questions. I have researched this a lot - and it's really working for me.
>
>
> > Just wondering how the selegiline and DLPA combo is working for you? (or anyone else who might be taking it, Kara?)
> >
>
>
I am not taking this now. I tried taking just selegiline 5 mg. for a couple of days. (I was going to add DLPA in the following days and possibly up the dosage of the selegiline to 10 mg. as the experiment progressed.) I had a somewhat paradoxical reaction to it though. I took it at around noon time and felt tired for most of the afternoon (had to drink a full cup of coffee which I don't usually do in the afternoon). Then around 9:00-10:00 that evening I started feeling the stimulation from it and couldn't sleep. So I decided that this might not be the best thing for me to try right now. I haven't given up on it entirely though (I just think that there may be some other health-related reasons that are standing in the way of this working well for me now) and I'm still holding out hope for the patch.Nemesis, if you have any insight into why I might have reacted like I did to the selegiline, I'd love to hear it. It would be easier to understand if I just had the initial paradoxical reaction. I don't suppose you reacted like that to it at first, did you?
I would love for this combination to work for me. It sounds so ideal - easy, inexpensive, clean and yet brain healthy (or so they claim).
Also, do you take anything for sleep with this regimen? It doesn't sound like it but I just wanted to be sure.
sfy,
If you do decide to try this, please post your results. I'd be very interested in seeing how your fared on it.
Kara
Posted by nemesis on September 15, 2004, at 18:34:18
In reply to Re: Selegiline Phenylalanine nemesis, posted by karaS on September 14, 2004, at 23:33:32
The first couple of days I had a variety of minor odd reactions, including headaches. These all passed within 3 days. The issue with insomnia took longer to pass, but it did. For the first week or two, there were a few nights when I had to take a couple Xanax or a few Neurontin and a half a Xanax in order to sleep. That also has passed, though. No need for the Xanax at all now, and I use the Neurontin only on the occasional odd day if my anxiety is up. Most new meds seems likely to come with some side effects, at least temporarily (Pamelor gave me paradoxical insomnia for months, not to mention other side effects that persisted the entire time I took it . . . constipation, dry mouth, weight gain, etc.). I'd stick it out for a few weeks and see how you feel. As for the patch, it's just going to be an MAOI unless you add in the DLPA for the extra kick.
> I am not taking this now. I tried taking just selegiline 5 mg. for a couple of days. (I was going to add DLPA in the following days and possibly up the dosage of the selegiline to 10 mg. as the experiment progressed.) I had a somewhat paradoxical reaction to it though. I took it at around noon time and felt tired for most of the afternoon (had to drink a full cup of coffee which I don't usually do in the afternoon). Then around 9:00-10:00 that evening I started feeling the stimulation from it and couldn't sleep. So I decided that this might not be the best thing for me to try right now. I haven't given up on it entirely though (I just think that there may be some other health-related reasons that are standing in the way of this working well for me now) and I'm still holding out hope for the patch.
>
> Nemesis, if you have any insight into why I might have reacted like I did to the selegiline, I'd love to hear it. It would be easier to understand if I just had the initial paradoxical reaction. I don't suppose you reacted like that to it at first, did you?
>
> I would love for this combination to work for me. It sounds so ideal - easy, inexpensive, clean and yet brain healthy (or so they claim).
>
> Also, do you take anything for sleep with this regimen? It doesn't sound like it but I just wanted to be sure.
>
> sfy,
> If you do decide to try this, please post your results. I'd be very interested in seeing how your fared on it.
>
>
> Kara
>
>
>
>
Posted by sfy on September 15, 2004, at 18:34:19
In reply to Re: Selegiline Phenylalanine nemesis, posted by karaS on September 14, 2004, at 23:33:32
> sfy,
> If you do decide to try this, please post your results. I'd be very interested in seeing how your fared on it.
>
>
> KaraI'm going to be starting next week (7 more days to wash out the mirtazapine) with 5 mg. of selegiline and 500 mg. of DLPA plus a B-Complex vitamin which I hope will help the absorption and avoid the high dosage problems associated with B-6.
Posted by sfy on September 15, 2004, at 18:34:19
In reply to Re: Selegiline Phenylalanine nemesis, posted by nemesis on September 15, 2004, at 8:16:26
Do you have anxiety due to the energizing effects? I'm just wondering because I have a history of Social Anxiety and am prone to mild (though noticeable) bouts of anxiety plus antidepressant-triggered anxiety symptoms (after two days on Zoloft I awoke to watch sweat pouring off my nose in rivulets).
Posted by nemesis on September 15, 2004, at 20:09:09
In reply to Re: Selegiline Phenylalanine nemesis, posted by sfy on September 15, 2004, at 13:21:09
I normally suffer from both generalized anxiety disorder and also social anxiety / agoraphobia. On the DLPA+selegiline+P-5-P, I have noticed diminished social anxiety (actually more social assertiveness) but somewhat increased general anxiety due to the energizing effects. All I can say is, the combo has so completely wiped out my seemingly interminable depression, that for me, this is only a minor issue. By the way, I couldn't even hack Zoloft for 2 days! SSRIs are not what my body needs . . . .
> Do you have anxiety due to the energizing effects? I'm just wondering because I have a history of Social Anxiety and am prone to mild (though noticeable) bouts of anxiety plus antidepressant-triggered anxiety symptoms (after two days on Zoloft I awoke to watch sweat pouring off my nose in rivulets).
Posted by karaS on September 15, 2004, at 21:16:02
In reply to Re: Selegiline Phenylalanine nemesis, posted by nemesis on September 15, 2004, at 8:16:26
Nemesis,
Thanks so much for all of your information.
I'm wondering if the stimulation much later in the day isn't more than just a minor reaction. I tend to react paradoxically to stimulants and I'm wondering if this will be the same way. I know that most stimulants don't work on PEA but I'm wondering if I have hypersensitive dopamine autoreceptors which would still end up giving me a lot of problems with selegiline. I guess I'd have to do the experiment to be certain but it's hard to work at all if you're having such strange reactions. I'll have to look into all of this more once my schedule is a little more stable.
Also, have you tried any other brands of DLPA and P5P? I have NOW brand P5P here but it also adds in a little zinc and something else. I wonder if that's a problem. The DLPA I have at home is Twinlab and Source Naturals. One is a capsule and the other is a tablet. Wonder if any of that matters too. I usually order from iHerb.com because their prices are good - but they don't carry Solgar.In terms of the selegiline, are you using pills or liquid? I've read that the liquid is better but that could just be more of a political issue.
I know that the patch isn't the same as what you're doing with adding in the raw materials from the DLPA - yet some treatment resistant depressives have reported great success when they used the patch in experimental trials. These same people have tried the pill form of selegiline with limited success. (Don't know if they tried adding in any DLPA.)
Anyway, sorry for running on so. I'm just very interested in this and I would love it if I could figure this all out and make it work for me.
Take care,
Kara
> The first couple of days I had a variety of minor odd reactions, including headaches. These all passed within 3 days. The issue with insomnia took longer to pass, but it did. For the first week or two, there were a few nights when I had to take a couple Xanax or a few Neurontin and a half a Xanax in order to sleep. That also has passed, though. No need for the Xanax at all now, and I use the Neurontin only on the occasional odd day if my anxiety is up. Most new meds seems likely to come with some side effects, at least temporarily (Pamelor gave me paradoxical insomnia for months, not to mention other side effects that persisted the entire time I took it . . . constipation, dry mouth, weight gain, etc.). I'd stick it out for a few weeks and see how you feel. As for the patch, it's just going to be an MAOI unless you add in the DLPA for the extra kick.
>
> > I am not taking this now. I tried taking just selegiline 5 mg. for a couple of days. (I was going to add DLPA in the following days and possibly up the dosage of the selegiline to 10 mg. as the experiment progressed.) I had a somewhat paradoxical reaction to it though. I took it at around noon time and felt tired for most of the afternoon (had to drink a full cup of coffee which I don't usually do in the afternoon). Then around 9:00-10:00 that evening I started feeling the stimulation from it and couldn't sleep. So I decided that this might not be the best thing for me to try right now. I haven't given up on it entirely though (I just think that there may be some other health-related reasons that are standing in the way of this working well for me now) and I'm still holding out hope for the patch.
> >
> > Nemesis, if you have any insight into why I might have reacted like I did to the selegiline, I'd love to hear it. It would be easier to understand if I just had the initial paradoxical reaction. I don't suppose you reacted like that to it at first, did you?
> >
> > I would love for this combination to work for me. It sounds so ideal - easy, inexpensive, clean and yet brain healthy (or so they claim).
> >
> > Also, do you take anything for sleep with this regimen? It doesn't sound like it but I just wanted to be sure.
> >
> > sfy,
> > If you do decide to try this, please post your results. I'd be very interested in seeing how your fared on it.
> >
> >
> > Kara
> >
> >
> >
> >
>
>
Posted by karaS on September 15, 2004, at 21:28:54
In reply to Re: Selegiline Phenylalanine KaraS, posted by sfy on September 15, 2004, at 13:16:57
> > sfy,
> > If you do decide to try this, please post your results. I'd be very interested in seeing how your fared on it.
> >
> >
> > Kara
>
> I'm going to be starting next week (7 more days to wash out the mirtazapine) with 5 mg. of selegiline and 500 mg. of DLPA plus a B-Complex vitamin which I hope will help the absorption and avoid the high dosage problems associated with B-6.
>Thanks. I have also read that taking vitamin C is good when you're on this regimen - but I don't think it's to be taken at the same as the DLPA.
I'll keep you posted if I try it again soon too.Good luck!
Kara
Posted by sfy on September 16, 2004, at 20:34:51
In reply to Re: Selegiline Phenylalanine KaraS » sfy, posted by karaS on September 15, 2004, at 21:28:54
> Thanks. I have also read that taking vitamin C is good when you're on this regimen - but I don't think it's to be taken at the same as the DLPA.
> I'll keep you posted if I try it again soon too.
>
> Good luck!
>
> Kara
>I'll have to check about Vitamin C and DLPA - the B-Complex I have includes C.
Posted by karaS on September 17, 2004, at 0:32:50
In reply to Re: Selegiline Phenylalanine nemesis, posted by nemesis on September 15, 2004, at 20:09:09
Did you have trouble with concentration before you went on the selegiline + DLPA? If so, has this combination taken care of that?
That has been one of my biggest problems though for some reason it seems to be better this week.
Posted by gromit on September 17, 2004, at 0:53:03
In reply to Re: Selegiline Phenylalanine » nemesis, posted by karaS on September 17, 2004, at 0:32:50
Hi, I wonder if someone could post a link to a study of this combo. My pdoc had never heard of selegiline, of course he had not heard of Cymbalta either and had to look to see if I could go above 10mg of Lexapro.
Is this medicine approved in the US? I thought Marplan, Parnate and Nardil were the only MAOI approved. It is cheap enough to order online but my insurance is actually pretty good for once so maybe they will pay.
I'm looking for something I can print out and take to my next appointment.
Thanks
Rick
Posted by LastDyingWish on September 17, 2004, at 1:11:24
In reply to Re: Selegiline Phenylalanine, posted by gromit on September 17, 2004, at 0:53:03
nemesis, i have been trying to get my doc to prescribe selegiline for quite some time now without luck, Iam very envious of your situation. you mentioned somthing about whole foods market, so i assume you live in so cal. if you dont mind me asking, perhaps we can communicate sometime. i live in so cal and have been looking for a more open minded p-doc. JS
Posted by sfy on September 17, 2004, at 11:33:38
In reply to Re: Selegiline Phenylalanine, posted by gromit on September 17, 2004, at 0:53:03
> Hi, I wonder if someone could post a link to a study of this combo. My pdoc had never heard of selegiline, of course he had not heard of Cymbalta either and had to look to see if I could go above 10mg of Lexapro.
>
> Is this medicine approved in the US? I thought Marplan, Parnate and Nardil were the only MAOI approved. It is cheap enough to order online but my insurance is actually pretty good for once so maybe they will pay.
>
> I'm looking for something I can print out and take to my next appointment.
>
> Thanks
> RickSelegiline is approved in the US. It's prescribed primarily for Parkinson's Disease and marketed under the brand name Eldelpryl. But it's also available in generic form.
As for studies, there's only one good one of Selegiline and DLPA (l-deprenyl is another name for selegiline):
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6425455The couple of other things published on this combo are pretty slim in terms of scientific rigor.
Posted by Terry on September 17, 2004, at 22:34:59
In reply to Re: Selegiline Phenylalanine nemesis, posted by nemesis on September 14, 2004, at 22:56:51
Don't you have to divide the doses of the Selegiline and DLPA to 2 or three times per day in order to avoid a drop off in blood levels?
Terry
Posted by gromit on September 18, 2004, at 0:30:26
In reply to Re: Selegiline Phenylalanine gromit, posted by sfy on September 17, 2004, at 11:33:38
> Selegiline is approved in the US. It's prescribed primarily for Parkinson's Disease and marketed under the brand name Eldelpryl. But it's also available in generic form.
>
> As for studies, there's only one good one of Selegiline and DLPA (l-deprenyl is another name for selegiline):
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6425455
>
> The couple of other things published on this combo are pretty slim in terms of scientific rigor.
Thank you.
Posted by joebob on September 18, 2004, at 8:58:35
In reply to Re: Selegiline Phenylalanine gromit, posted by sfy on September 17, 2004, at 11:33:38
nervous when taken together....
what are good doses?
how about tyrosine?thanks
Posted by sfy on September 18, 2004, at 13:48:05
In reply to i found that Selegiline Phenylalanine made me » sfy, posted by joebob on September 18, 2004, at 8:58:35
> nervous when taken together....
> what are good doses?
> how about tyrosine?
>
> thanksIt is supposed to be activating so for some people it will increase anxiety - I've found in the past that sometimes medication-related anxiety reduces over time. I have to wait till next week to see how this combo affects my anxiety.
The usual dose of selegiline is 5 to 10 mg a day usually taken with breakfast. (Though I've seen some people mention that they take 2.5 mg). Anything more than 10 mg and you run the risk of selegiline becomine a non-selective MAOI complete with all the dietary restrictions. The DLPA dosage is usually 500 to 1000 mg taken first thing in the morning.
I know that phenylalanine is a tryrosine precursor but I haven't seen anything which directly addresses taking tyrosine with selegiline.
Posted by karaS on September 18, 2004, at 22:48:39
In reply to i found that Selegiline Phenylalanine made me » sfy, posted by joebob on September 18, 2004, at 8:58:35
> nervous when taken together....
> what are good doses?
> how about tyrosine?
>
> thanks
Tyrosine wouldn't provide the PEA which is the reason behind combining selegiline with phenylalanine.-K
Posted by SFY on September 27, 2004, at 12:40:39
In reply to Re: Selegiline Phenylalanine nemesis, posted by karaS on September 14, 2004, at 23:33:32
> sfy,
> If you do decide to try this, please post your results. I'd be very interested in seeing how your fared on it.
>
>
> KaraI'm on my second day of 500 mg. of DLPA and 5 mg. of Selegiline. So far, no apparent effect as far as I can tell. All I've noticed is a low-grade slightly buzzy headache but no change in energy or focus that jumps out at me.
I'll keep you posted on any further developments (and I think I'll move this to the main board instead of Alternative).
Posted by karaS on September 27, 2004, at 17:06:10
In reply to Re: Selegiline Phenylalanine » karaS, posted by SFY on September 27, 2004, at 12:40:39
> > sfy,
> > If you do decide to try this, please post your results. I'd be very interested in seeing how your fared on it.
> >
> >
> > Kara
>
> I'm on my second day of 500 mg. of DLPA and 5 mg. of Selegiline. So far, no apparent effect as far as I can tell. All I've noticed is a low-grade slightly buzzy headache but no change in energy or focus that jumps out at me.
>
> I'll keep you posted on any further developments (and I think I'll move this to the main board instead of Alternative).
>Thanks for keeping me posted. I don't remember how long it took before Nemesis got an antidepressant response, do you? I'm keeping my fingers crossed that it will kick in for you!
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