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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by ace on May 6, 2004, at 20:46:13
Just want to mention after my third day on 15mg Remeron combined with 75mg Nardil and 2.5mg Olanzapine...everything is sweet as!
Not one problem so far...and the Remeron sedation at night is great! Lovely easy sleep!
After just 3 days I'm sure a bit of an AD effect is kicking in....but the best is yet to come.
SO...MAOI + REMERON IS ABSOLUTELY SAFE!!!I'm even thinking of writing to Pubmed to tell them this is the case!
Ace
Nardil 75
Zyprexa 2.5
Remeron 15
Posted by Civ on May 6, 2004, at 20:49:42
In reply to NARDIL + REMERON is very safe!!! Great combo!!!, posted by ace on May 6, 2004, at 20:46:13
That's excellent, bro! Ace, how is the Zyprexa working for you? I really need some help to conquer my OCD and BDD and I'm not sure that a high dose SSRI is the answer.
Posted by ace on May 6, 2004, at 20:55:24
In reply to Re: NARDIL + REMERON is very safe!!! Great combo!!! ace, posted by Civ on May 6, 2004, at 20:49:42
> That's excellent, bro!
Thanks so much man!!
Ace, how is the Zyprexa working for you?For my OCD, Zyprexa 2.5 is a miracle. It has wiped out an obsessional and extremely painful gut-wrenching thought pattern. For OCD i am in awe of its effects.
It hasn't really done much for anxiety or depression, but, like I said, for OCD it is a blessing. I will remain on it at least a year or two.
I really need some help to conquer my OCD and BDD and I'm not sure that a high dose SSRI is the answer.If you have tried a couple of SSRIs high dose, I'd say move on dude. Try Anafranil, Remeron, Zyprexa....Luvox (have u tried this? It seems by far the best anti-OCD SSRI, Zoloft is the weakest anti-OCD SSRI)
There is soooo much you can try man! Feel free to ask me any qstns!!
Take care mate,Ace
Posted by Questionmark on May 7, 2004, at 0:14:06
In reply to NARDIL + REMERON is very safe!!! Great combo!!!, posted by ace on May 6, 2004, at 20:46:13
> Just want to mention after my third day on 15mg Remeron combined with 75mg Nardil and 2.5mg Olanzapine...everything is sweet as!
>
> Not one problem so far...and the Remeron sedation at night is great! Lovely easy sleep!
>
> After just 3 days I'm sure a bit of an AD effect is kicking in....but the best is yet to come.
>
>
> SO...MAOI + REMERON IS ABSOLUTELY SAFE!!!
>
> I'm even thinking of writing to Pubmed to tell them this is the case!
>
>
> Ace
> Nardil 75
> Zyprexa 2.5
> Remeron 15
That is really great. It just goes to support my belief that many drugs that are usually contraindicated with MAOIs (esp.ly Nardil) are, in actuality, quite safe (with the definite exception, of course, of SRIs, serotonin agonists, and NE releasers/agonists) (even cautious use of NARIs are most likely safe with MAOIs due to in part to their ability to prevent neuronal tyramine storage/uptake!).
Writing to PubMed is a great idea.Two questions:
1) Do you find that the Remeron counteracts any of Nardil's beneficial effects? i'm wondering since 5-HT receptor antagonists are sometimes believed to counteract a serotonergic med.'s beneficial effects. Also, i feel like this occurred with me to some extent when i took/take cyproheptadine.
2) If you don't mind saying, are you having any anorgasmic difficulties? i certainly am (and only on 45mg Nardil, currently), and i would suspect that the Zyprexa might make it even worse. And i am interested in trying very lose dose Zyprexa (2.5mg is probably all i could handle) to see if its sometimes marvelous-sounding antiobsessional benefits would be present with me. My depression and SA have been greatly reduced thanks to Nardil, but my OC*P*D -type symptoms are still ruining my life, and therapy has not been helping, unfortunately.
Anyway, good to hear the positive news and much thanks for commenting on my questions if you do.
Posted by tamdon on May 7, 2004, at 2:48:10
In reply to Re: NARDIL + REMERON is very safe!!! Great combo!!! Civ, posted by ace on May 6, 2004, at 20:55:24
How do you know that the combination is safe. Also, that seems a prescription for weight gain. Any problem with that for you?
Posted by Sad Panda on May 7, 2004, at 3:43:51
In reply to NARDIL + REMERON is very safe!!! Great combo!!!, posted by ace on May 6, 2004, at 20:46:13
> Just want to mention after my third day on 15mg Remeron combined with 75mg Nardil and 2.5mg Olanzapine...everything is sweet as!
>
> Not one problem so far...and the Remeron sedation at night is great! Lovely easy sleep!
>
> After just 3 days I'm sure a bit of an AD effect is kicking in....but the best is yet to come.
>
>
> SO...MAOI + REMERON IS ABSOLUTELY SAFE!!!
>
> I'm even thinking of writing to Pubmed to tell them this is the case!
>
>
> Ace
> Nardil 75
> Zyprexa 2.5
> Remeron 15
>
>Hi Ace,
Even though I think MAOI + Remeron is fine I would still move cautiously. Remeron has so much affinity for H1 receptors relative to other receptors that at low doses it only acts as a pure antihistamine. At 30mg Remeron starts to antagonize Alpa-2 NE receptors & this will feel stimulating or irratating. On this board I have noticed a lot of people complain about crankiness & anger & this was a problem for me for at least a month after increasing my dosage from 15 to 30mg.
Cheers,
Panda.
Posted by SLS on May 7, 2004, at 8:41:05
In reply to Re: NARDIL + REMERON is very safe!!! Great combo!!! ace, posted by Sad Panda on May 7, 2004, at 3:43:51
Ace,
> Even though I think MAOI + Remeron is fine I would still move cautiously. Remeron has so much affinity for H1 receptors relative to other receptors that at low doses it only acts as a pure antihistamine. At 30mg Remeron starts to antagonize Alpa-2 NE receptors & this will feel stimulating or irratating. On this board I have noticed a lot of people complain about crankiness & anger & this was a problem for me for at least a month after increasing my dosage from 15 to 30mg.
I agree with Panda. I hope this stuff works for you. You may have discovered a new formula for California Rocket Fuel.
- Scott
Posted by gabadabavodoo on May 7, 2004, at 11:26:46
In reply to Re: NARDIL + REMERON is very safe!!! Great combo!!!, posted by tamdon on May 7, 2004, at 2:48:10
I hope it does work, but you cant judge it after 3 days. It causes your appetite to increase, so hence weight gain in many people. Sexual side effects depend on the person. The real test should come after being on it for a good length of time.
When i first stared on it, it seemed wonerdful, but it soon lost its initial effect. Then came the side effects. I started to not ejaculate at all.
Now i relaize everyone has their own sensitivity to drugs, and my case is unusal, but real just tha same.
I stll sleep great, but im tryigng different things to conteract this horible sexual side effect. I almost prefer the LIVING HELL of Paxil to this side effect. At least with Paxil i would ejaculate, even it it was delayed. I am really against Paxill as you can tell. It took me a full year top recover from being on that HORRIBLE DRUG. I dont think i am quite the same today.
I too felt weird at first. I couldnt explain it. It wasnt cranky or angry, it was a strange feeling. It was an uncomfortable feeling. It relaxed me, but almost to the point where i felt too relaxed, if thats possible. I think that is the angry., cranky feeling people refer to?
That goes away. So does any of the grogginess that you feel at first. It disappears. The great feeling you get when you first start taking it also goeas away unfortunetly, or at least it did for me.
When i first was on it, i was also telling everyone how great it is, and how there are no side effects, now i have to eat crow.
ITS A DRUG. There is no perfect drug.It has not been the greatest thing for depression, but it has allowed me to sleep through the night, which has been a boost for my depression.
I dont mean to be negative, i hope it works for you, but it has failed to deliver in the long run as far as depression is concerned.
gabadabavodoo
Posted by jaby on May 7, 2004, at 12:13:05
In reply to NARDIL + REMERON is very safe!!! Great combo!!!, posted by ace on May 6, 2004, at 20:46:13
Fat combo too! Be sure to be counting your carbs if that's of concern.
Posted by ace on May 13, 2004, at 23:42:34
In reply to Re: NARDIL + REMERON is very safe!!! Great combo!!! ? ace, posted by Sad Panda on May 7, 2004, at 3:43:51
> > Just want to mention after my third day on 15mg Remeron combined with 75mg Nardil and 2.5mg Olanzapine...everything is sweet as!
> >
> > Not one problem so far...and the Remeron sedation at night is great! Lovely easy sleep!
> >
> > After just 3 days I'm sure a bit of an AD effect is kicking in....but the best is yet to come.
> >
> >
> > SO...MAOI + REMERON IS ABSOLUTELY SAFE!!!
> >
> > I'm even thinking of writing to Pubmed to tell them this is the case!
> >
> >
> > Ace
> > Nardil 75
> > Zyprexa 2.5
> > Remeron 15
> >
> >
>
> Hi Ace,
>
> Even though I think MAOI + Remeron is fine I would still move cautiously. Remeron has so much affinity for H1 receptors relative to other receptors that at low doses it only acts as a pure antihistamine. At 30mg Remeron starts to antagonize Alpa-2 NE receptors & this will feel stimulating or irratating.Panda please read my below post "Remeron concerns"....do u believe this is whats happening to me??? will the unhinged, feeling dissipate in time or must I lower to 15mg you think??
On this board I have noticed a lot of people complain about crankiness & anger & this was a problem for me for at least a month after increasing my dosage from 15 to 30mg.
>
> Cheers,
> Panda.
>
>
>
Posted by FredPotter on April 2, 2015, at 6:47:32
In reply to Re: NARDIL + REMERON is very safe!!! Great combo!!! ace, posted by Civ on May 6, 2004, at 20:49:42
This paper by the neuropharmacologist Dr Ken Gillman, who is an expert in Serotonin Toxicity (ST), explains why Nardil and other MAOIs in conjunction with mirtazapine (Remeron) are safe.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20655983.
He found that there is no evidence that Remeron is a dual action drug (serotonin and norepinephrine) but a noradrenergic drug with a blockade of some serotonin receptor subtypes, especially 5-HT2A, thus indirectly agonising the 5-HT1A receptors, which has a mood-brightening effect. A further paper, the authors of which I can't remember, says in fact that Remeron can be used to TREAT serotonin toxicity
Posted by FredPotter on April 2, 2015, at 7:04:01
In reply to REMERON seems very safe, but it is sneaky, posted by gabadabavodoo on May 7, 2004, at 11:26:46
> I hope it does work, but you cant judge it after 3 days. It causes your appetite to increase, so hence weight gain in many people. Sexual side effects depend on the person. The real test should come after being on it for a good length of time.
>
> When i first stared on it, it seemed wonerdful, but it soon lost its initial effect. Then came the side effects. I started to not ejaculate at all.
>
> Now i relaize everyone has their own sensitivity to drugs, and my case is unusal, but real just tha same.
>
> I stll sleep great, but im tryigng different things to conteract this horible sexual side effect. I almost prefer the LIVING HELL of Paxil to this side effect. At least with Paxil i would ejaculate, even it it was delayed. I am really against Paxill as you can tell. It took me a full year top recover from being on that HORRIBLE DRUG. I dont think i am quite the same today.
>
> I too felt weird at first. I couldnt explain it. It wasnt cranky or angry, it was a strange feeling. It was an uncomfortable feeling. It relaxed me, but almost to the point where i felt too relaxed, if thats possible. I think that is the angry., cranky feeling people refer to?
>
> That goes away. So does any of the grogginess that you feel at first. It disappears. The great feeling you get when you first start taking it also goeas away unfortunetly, or at least it did for me.
>
> When i first was on it, i was also telling everyone how great it is, and how there are no side effects, now i have to eat crow.
>
>
> ITS A DRUG. There is no perfect drug.
>
> It has not been the greatest thing for depression, but it has allowed me to sleep through the night, which has been a boost for my depression.
>
> I dont mean to be negative, i hope it works for you, but it has failed to deliver in the long run as far as depression is concerned.
>
> gabadabavodooI assume you're talking about Remeron. In which case there shouldn't be sexual side effects, although Nardil has them. Prof Preskorn on preskorn.com even suggests combining Remeron with SSRIs to eliminate the sexual side effects. Needless to say, you should work with a professional when doing this. If the initial good effect of Remeron dwindles, isn't it time to increase the dose?
Posted by FredPotter on April 3, 2015, at 0:11:18
In reply to Re: NARDIL + REMERON is very safe!!! Great combo!!!, posted by FredPotter on April 2, 2015, at 6:47:32
Sorry I posted the wrong link. I'll post the right one presently
This is the end of the thread.
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