Posted by Cam W. on February 28, 2001, at 10:28:19
In reply to Re: Which is worse: Zyprexa weight gain or Risperdal » Cam W., posted by SLS on February 28, 2001, at 6:59:19
Scott - Another theory that I have (proposed by Phil Seeman, the guy who discovered the receptor site theory) is that the "tweaking' of the dopamine-D2 receptor by the atypical antipsychotics causes different secondary messenger signaling than if the D2 receptor is irreversibly bound by the traditional antipsychotics.
I read an article yesterday where the immune system my play a role in the action and side effects of antipsychotics via activations of different cytokine systems by different antipsychotics. This may explain some of the mechanism of action and especially some of the side effect differences of antipsychotics in general (esp. weight gain with Clozaril and Zyprexa & blood problems with Clozaril). The journal article is:
Pollmacher T, et al. Effects of antipsychotic drugs on cytokine networks. J.Psychiatric Res; 34(2000): 369-382.
Pages 374 to 376 are most interesting, even though most of the article in inconclusive.
This journal article can be obtained by signing up to the "geek site":
and going to the library and surfing the available journals. The give you 120 free credits and to view &/or copy a journal article costs 4 credits (hence 30 free articles). Most of the journals are fairly "heady" stuff, but sifting through them is interesting to geeks like me and you. I'm not sure if you have to be a health professional to sign-up, but I'm sure you could fake it.
P.S. I've used up all my credits, plus all of the extra credits they have given me. Mention my name when you sign-up and maybe I'll get some more (I doubt it though). Maybe I shouldn't be so cheap and shell out the $199US for the premium package. Alas, time to hit up the boss for another raise.
Happy surfing - Cam
poster:Cam W.
thread:55031
URL: http://www.dr-bob.org/babble/20010221/msgs/55102.html