Posted by SalArmy4me on July 22, 2001, at 0:27:53
In reply to Re: What do I do now?, posted by Else on July 21, 2001, at 20:01:47
Serzone's AD action is probably not linked to its ability to create serotonin reuptake inhibition:
http://www.preskorn.com/cgi-bin/sp.pl?words=nefazodone&wt=be&bl=an&d=/books/omd_s8.html
"Nefazodone likely only produces serotonin (5-HT)-2A inhibition at doses £ 300 mg/day and even at doses of 500 mg/day does not appear to produce the same degree of the serotonin reuptake inhibition as occurs with the SSRIs and venlafaxine at their starting doses.150 This pharmacology is consistent with the clinical advantages and disadvantages of nefazodone..."
"All of the above factors cause an apparently greater degree of interpatient variability in terms of response to nefazodone than is true for many of the other new antidepressants. Nevertheless, nefazodone can be a useful antidepressant option for the primary-care practitioner for selected patients such as those who do not tolerate the adverse effects caused by serotonin reuptake inhibition..."
poster:SalArmy4me
thread:71077
URL: http://www.dr-bob.org/babble/20010720/msgs/71295.html