Posted by Else on July 22, 2001, at 8:43:01
In reply to Serzone » Else, posted by SalArmy4me on July 22, 2001, at 0:27:53
Then what does it do? At this point, I'm pretty convinced I need an AD that act on NE or DA (or both) or a stimulant. I can't take Effexor, the serotoninergic effect is too strong and Wellbutrin make me twitch. At this point, I'm pretty sure a stimulant/benzo combo would do the trick but I'm trying to work up the nerve to ask my doctor for this. I think Canada is stricter on the use of stimulants for something other than narcolepsy and childhood ADHD than the US is but that might have more to do with doctor's beliefs than with the law. I'll look up Serzone but if it's in any way like Desyrel I am not taking it. It's the worst drug I ever took.
Thanks Sal
> Serzone's AD action is probably not linked to its ability to create serotonin reuptake inhibition:
>
> http://www.preskorn.com/cgi-bin/sp.pl?words=nefazodone&wt=be&bl=an&d=/books/omd_s8.html
>
> "Nefazodone likely only produces serotonin (5-HT)-2A inhibition at doses £ 300 mg/day and even at doses of 500 mg/day does not appear to produce the same degree of the serotonin reuptake inhibition as occurs with the SSRIs and venlafaxine at their starting doses.150 This pharmacology is consistent with the clinical advantages and disadvantages of nefazodone..."
>
> "All of the above factors cause an apparently greater degree of interpatient variability in terms of response to nefazodone than is true for many of the other new antidepressants. Nevertheless, nefazodone can be a useful antidepressant option for the primary-care practitioner for selected patients such as those who do not tolerate the adverse effects caused by serotonin reuptake inhibition..."
poster:Else
thread:71077
URL: http://www.dr-bob.org/babble/20010720/msgs/71324.html