Posted by SLS on April 1, 2002, at 13:22:44
In reply to Re: Zyprexa *never* for depression!, posted by OldSchool on March 31, 2002, at 20:12:58
> > If people need the 5HT antagonism for anxiety, why not just add a safer med like serzone or trazodone?
> >
> > Any thoughts...
> >
> > Your Friend,
> >
> > Tye
>
>
> Thats exactly what I say. If you just need 5HT2A receptor antagonism for anxiety, agitation, insomnia or other non direct psychotic/mania stuff, why not just take Remeron, Serzone or Trazadone? As Tye mentioned, all three of these antidepressants antagonise 5HT2A. Remeron in particular does it real real good. Why risk EPS and even TD by going the atypical anti-psychotic route?
>
> Old SchoolHi.
I don't think we as a species can yet proclaim an understanding as to how drugs work to alleviate depression - especially on an individual basis.
There may be a modulation of dopaminergic function that is essential to the efficacy of atypical neuroleptics in depression. Consider sulpiride and amisulpride. Both of these neuroleptic antipsychotic drugs are putatively effective in treating depression and dysthymia, and are marketed for those indications around the world. Both antagonize DA D2 receptors. Neither antagonizes 5-HT2 receptors.
- Scott
poster:SLS
thread:100817
URL: http://www.dr-bob.org/babble/20020327/msgs/101301.html