Re: What Zyprexa is excellent for - Old School » Denise528

Posted by SLS on April 2, 2002, at 7:59:30

In reply to Re: What Zyprexa is excellent for - Old School, posted by Denise528 on April 2, 2002, at 6:03:37

> Also, can somebody please explain to me the difference between antagonising a receptor and agonising one?
>
> Thanks.....Denise

Hi Denise.
When speaking of neurotransmission, the words "agonize" and "antagonize" refer to the effect that a drug (molecule) has when it attaches itstelf to a receptor.
AGONIZE = attach to and stimulate a receptor; cause is to perform its function
ANTAGONIZE = attach to and block/inhibit a receptor; prevent it from performing its function
---------------------------------
DA = dopamine
DA2 or D2 = dopamine receptor (type-2)
Zyprexa = DA2 antagonist
Mirapex = DA2, DA3 agonist
Generally, the neuroleptic type of antipsychotic antagonize dopamine receptors and reduce the excitability and firing rate of neurons.

- Scott

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