Posted by Philidor on August 24, 2004, at 11:42:14
In reply to Re: The *Real* Truth - zeugma too » KaraS, posted by zeugma on August 23, 2004, at 18:58:31
To Zeugma:
"i can do little other than post the results of my own experiments in reducing stim tolerance- see my post in reply to alesta further down."Well, where the heck IS that post? I'd like to see those results.
Concerning NMDA antagonists, you are quite right in saying that, NMDA antagonists (such as dextromethorphan (DMX)), should be worthless at best for inhibiting tolerance to morphine. But in one study it not only did, but REVERSED tolerance in human patients. Incredible? Well, the researchers who did the study thought so too:
"When we received the results from the first experiment, I couldn't believe it. Everything we knew up to that point indicated that it shouldn't work - but it did!" (said Dr.)Jhamandas."
http://opioids.com/tolerance/paincontrol.html
Apparently, DXM's biochemical action is dose-related. In micro-doses, it seems to work in reverse and becomes an NMDA agonist!
But this is just one study, and needs furthur investigation.
Phil
poster:Philidor
thread:380561
URL: http://www.dr-bob.org/babble/20040821/msgs/381710.html