Posted by SLS on August 25, 2004, at 8:07:54
In reply to Re: The *Real* Truth - zeugma too » SLS, posted by zeugma on August 25, 2004, at 7:29:02
I don't know if this will add anything to what you already know, but...
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Nortriptyline: increased slightly by methylphenidate 2D6Nortriptyline: decreased slightly by modafinil 3A
Buspirone: decreased by modafinil 3A
Methylphenidate: increased slightly by nortriptyline 2D6
Modafinil: no change
Clonazepam: decreased by modafanil 3A
Clonazepam active metabolite: increased due to induction on parent compound..... "This therapeutically active metabolite may be increased because the parent compound's metabolism is induced by a cytochrome. The effect is like opening a flood gate leading to an increased level of the metabolized drug. This is especially significant if the metabolite contributes significantly to the therapeutic effect or the metabolite is the active drug and the drug given is not pharmacologically active."
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The program was published by a group from Harvard University. I think it is important to note that these interactions are "on paper" and that each and every one has not been determined clinically.
- Scott
poster:SLS
thread:380561
URL: http://www.dr-bob.org/babble/20040825/msgs/382041.html