Posted by zeugma on August 25, 2004, at 5:32:44
In reply to Re: The *Real* Truth - zeugma too » zeugma, posted by Dave001 on August 24, 2004, at 20:30:52
Note that modafinil also causes significant induction of the CYP3A4/5 enzymes, and is an inducer of its own metabolism.
Dave
yes i know that. i take buspirone (30 mg) and clonazepam (1 mg) which could be affected by this. i'm not worried about the buspirone because that drug has such a short half life, and its metabolite (which will increase as a result of enzyme induction)is an alpha 2 antagonist which probably has a therapeutic effect for me. the clonazepam is more serious but i was taking Provigil for over a month at dosages up to 100 mg/day and did not notice increases in anxiety.
the problem is that i'm also taking nortriptyline 100 mg/day and that makes 5 meds taken concurrently which could be very complicated. if anything 3A induction would lower nortriptyline levels slightly. but it's the effect of all 5 that concerns me.
-z
poster:zeugma
thread:380561
URL: http://www.dr-bob.org/babble/20040825/msgs/382014.html