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Re: Neurontin to Topomax » Larry Hoover

Posted by ed_uk on June 6, 2005, at 15:15:02

In reply to Re: Neurontin to Topomax » ed_uk, posted by Larry Hoover on June 6, 2005, at 13:02:42

Hi Lar,

Topamax is a carbonic anhydrase inhibitor. Acetazolamide is a carbonic anhydrase inhibitor which is used to treat glaucoma. Topamax and acetazolamide *share* many side effects.

Common side effects shared by Topamax and acetazolamide...........

Taste disturbances, loss of appetite, weight loss, paresthesia (numbness/tingling), fatigue, kidney stones etc.

Have a look at this.........................

Carbonic anhydrase inhibitor side effects. Serum chemical analysis.

Epstein DL, Grant WM.

Multiple serum chemical values were examined in 92 patients with chronic glaucoma who were treated with the carbonic anhydrase inhibitors (CAIs) acetazolamide or methazolamide, seeking relationships between serum composition and symptomatic side effects. Of the 92 patients, 44 complained of a symptom-complex of malaise, fatigue, weight loss, depression, anorexia, and loss of libido, which we have found most commonly to threaten continuation of therapy. Patients who had this symptom complex were significantly more acidotic than those without it. Ten of 24 patients who had chemical evidence of excessive acidosis reported a dramatic alleviation of symptoms when sodium bicarbonate was administered.

Ed.


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URL: http://www.dr-bob.org/babble/20050606/msgs/508614.html