Posted by tecknohed on October 18, 2005, at 19:49:33
In reply to Re: NRP104 - D-amphetamine bonded with Lysine?, posted by med_empowered on October 18, 2005, at 9:49:22
> Delayed-onset can reduce abuse potential **alot**...look the barbiturates. Seconal--fast onset, highly abusable...Phenobarbital--slooooow onset, sloooooow course of action--schedule IV, still kinda popular. Benzos--xanax vs klonopin. Until they run trials in people (especially people with histories of illcit drug use), no one will know for sure but...it would *appear* that they may be able to make amphetamines considerably less abusable.
I see what you mean. I guess I'm just looking at it from a different angle. For someone with no history of drug abuse, the delayed onset would avoid the (almost) instantanious high and so less likely to create an 'instant reward syndrome'. However I do feel that, for those who already abuse/have abused, NRP104 would be no less abusable than normal amphetamine. More convenient even, removing the need to keep 'topping up' - a nice even high throughout the day, just a bit of patience required!
Could it be though, that with such a slow onset of action (assuming it has a 'slow' onset and not just a 'delayed' onset), it wouldn't trigger such a marked effect on DA - an effect yes, but with a more steady re-uptake mechanism without the sudden DA boost/release that occures with standard faster acting amphetamine which instead hits the brain all at once? If so, I can see how this might avoid any downregulation which normally leads to 'crash', craving and tolerence.
Maybe I just think too much (sigh).
teck.
poster:tecknohed
thread:567520
URL: http://www.dr-bob.org/babble/20051017/msgs/568651.html