Posted by ADHDdoc on April 10, 2006, at 16:32:49
In reply to Re: NRP104 - D-amphetamine bonded with Lysine? » Larry Hoover, posted by Shawn. T. on October 22, 2005, at 15:49:40
I read with interest the October, 2005 discussion between Shawn T. and Larry Hoover about NRP104 and its possible mechanisms of metabolism. Six months later, is there any more information about how NRP104 is metabolized? Since New River describes the metabolism as being dependent on "GI enzymes," I wondered whether any of the Cytochrome P450 enzymes might need to be called upon to cleave the lysine off of the d-amphetamine molecule. If so, might this not increase the potential for drug-drug interactions, particularly if an ADHD patient were taking something else that were an inhibitor or a substrate of the same enzyme?
poster:ADHDdoc
thread:567520
URL: http://www.dr-bob.org/babble/20060408/msgs/631477.html