Posted by Larry Hoover on October 27, 2005, at 14:15:11
In reply to Re: NRP104 - D-amphetamine bonded with Lysine? » Larry Hoover, posted by Shawn. T. on October 22, 2005, at 15:49:40
Shawn, I'm sorry. Did I say something to make you feel under criticism?
The manufacturer's claims are not fully consistent with simple physiology. As I suggested, stomach acid would initiate hydrolysis of the dimer. The pancreatic enzyme trypsin, secreted in the duodenum, has some specificity for lysine, and would likely finish the job. However, I do not know of any evidence to support a claim of a "saturation effect", in this instance. If it did come to bear on the kinetics here, I'd have to suggest that it would occur only at doses far above those expected from prescribed amounts.
As Chairman MAO points out, and my comments infer, it would be simple to cleave the amphetamine from the lysine. The prodrug would have little effect if injected or snorted as supplied, but it's not too difficult to defeat the CBD safety feature, and liberate the amphetamine.
It's hard to know just what was observed in their trials, as nothing I can find has been published. As they are also CBD delivery systems for opiate analgesics, we can expect some serious scrutiny. Until we see some data, we will be restricted to opinionated speculation. I'm sorry if my thoughts left anyone feeling unhappy. I purposely posted to the thread, and not to an individual.
Lar
poster:Larry Hoover
thread:567520
URL: http://www.dr-bob.org/babble/20051024/msgs/572419.html