Posted by Pops_1 on June 15, 2006, at 12:44:48
In reply to Re: EMSAM stronger than oral selegline, posted by notfred on June 14, 2006, at 17:50:40
>
> >
> > b. MAO-A inhibition is what produces antidepressant efficacy
>
> I have already posted studies to bear out this.> >
> > c. MAO-A inhibition is what creates dietary restrictions
> >
>
> see http://www.biopsychiatry.com/pressor.htmBoth of these statements are correct and are confirmed in the monograph I cited. I was trying to clarify that your OTHER two apparent assumptions were incorrect, and hence dispel any suggestion that EMSAM 20mg doesn't require dietary restrictions because it doesn't inhibit cortical MAO-A.
- "a. EMSAM & deprenyl dosing were equivalent (e.g., if you needed 40mg-60mg oral dose for AD, you would need 40-60mg EMSAM dose for AD)"
- "d. Since EMSAM 20mg doesn't have dietary restrictions, it must not inibit MAO-A"
Is this what you were suggesting? If not, what is your point about EMSAM 20mg?
I provided the quotes from the monograph to demonstrate that EMSAM 20mg achieves its status as "MAOI without dietary restrictions" by producing therapeutic inhibition of brain MAO-A without impacting GI MAO-A, not because it only inhibits MAO-B.
I think this is important to clarify, since someone currently on a traditional MAOI might infer from your post that they would have to go to the dietary-restricted EMSAM doses to get the same benefits, which is probably not the case.
poster:Pops_1
thread:655515
URL: http://www.dr-bob.org/babble/20060610/msgs/657255.html