Posted by Jakeman on June 15, 2006, at 22:44:06
In reply to Re: EMSAM stronger than oral selegline, posted by Pops_1 on June 15, 2006, at 12:47:57
Hi Pops notfred and others,
Very good article, thanks for posting:
http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=400One sentence concerns me:
Mechanism of Antidepressant Action of Selegiline Transdermal System
"Interestingly, the acute increases in brain 5-HT and NE with MAOIs subside with continued treatment and the levels gradually return to the pre-treatment state due to end-product inhibition of biosynthesis and adaptive changes in the neurotransmitter receptor sensitivity.1 " (I'd like to find this article).They seem to imply that poop-out will occur just like so many other AD's.
But other studes say a minimum 1 year efficacy is predicted:
"It seems that improvement seen in short-term trials is maintained for at least 1 year with continued STS treatment. The data from the three trials as well as an unpublished trial (data submitted to the FDA) are summarized in Table 5."
Another part of the article comments on the oral vs transdermal potency which has discussed on this board:
"STS also was 10–20 times more potent than oral selegiline in producing its antidepressant-like effect and inhibiting cortical MAO-A.10"
I tried to reseach the studies they cited but couldn't find much detail, just the abstracts. I've read that other people complain about MAOI poop-out. I wonder if that's also the case with Emsam. As they always say, more research may be needed.
~Jake
poster:Jakeman
thread:655515
URL: http://www.dr-bob.org/babble/20060610/msgs/657463.html