Posted by circusboy on February 22, 2007, at 22:30:23
In reply to Re: Lamictal effects by day 5? PDoc says 'no', posted by Joe Bloe on February 22, 2007, at 17:06:08
> When you say "binding to nicotonic receptors," does this mean that Lam has an effect similar to nicotine (does nicotine also effect the sodium channels?), or is it the opposite? I had a cigarette on the Lam and I felt like I had smoked 3 at once, which makes me think it is the former.
>I'm thinking it's anticholinergic (or antinicotinic, anyway), from the last line of the abstract... and from comparing my experience with Lamictal to my experiences with desipramine and nortriptyline.
I don't know enough neuroscience to understand exactly what's going on here... Anyone else? Anyway, here's the abstract:
* * *
Neuroreport. 2007 Jan 8;18(1):45-50.Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor.
Valles AS, Garbus I, Barrantes FJ.UNESCO Chair of Biophysics and Molecular Neurobiology and Instituto de Investigaciones Bioquimicas de Bahia Blanca, Bahia Blanca, Buenos Aires, Argentina.
Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closed-time component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on the muscle nicotinic acetylcholine receptor.
PMID: 17259859 [PubMed - in process]
poster:circusboy
thread:734880
URL: http://www.dr-bob.org/babble/20070219/msgs/735244.html