Posted by psychobot5000 on February 23, 2007, at 0:43:42
In reply to Re: Does Lamictal plus cholinergic make sense?, posted by Joe Bloe on February 23, 2007, at 0:27:37
I agree that this is interesting...especially as it -conceivably- makes it possible to avoid Lamictal's side-effects.
>Now, if Lamictal is anticholinergic, (and if the primary therapeutic action of Lamictal is its anticholinergic effect, then does taking cholinergic drugs and supplements potentially mitigate any benefit from Lamictal?
>Well, maybe. But it seems to me possible (assuming Lamictal is actually anticholinergic, of course) that Lamictal might have antinicotinic/anticholinergic side-effects (the cognitive ones), while its theraputic effect is caused by something else. While Lamictal is definitely not well understood (and may not have long term mood-benefits, lets not forget), researchers seem to believe its effects on the GABA and glutamate systems are likely responsible for its mood effect.
> Or does Lamictal have other therapeutic properties that makes it worthwhile to take the drug while trying to limit it anticholinergic properties?
Maybe so? It seems to me a perfectly good idea to at least -try- aricept (or another cholinesterase inhibitor) as an antidote to the thinking issues--It would certainly help us learn something, I think, if that worked. For me, psychostimulants were unhelpful, but maybe (?) something increasing Acetylcholine would act more directly?I would like to remind anyone reading this that some people seem to believe cholinesterase inhibitors can lower one's mood or cause depression. I don't know how real the possibility is.
Best,
Psychbot
poster:psychobot5000
thread:734880
URL: http://www.dr-bob.org/babble/20070219/msgs/735263.html