Posted by psychobot5000 on October 26, 2007, at 14:18:50
In reply to Re: Dopamine agonists cause sedation. But why?? » djmmm, posted by amigan on October 26, 2007, at 5:20:59
Why dopamine agonists causes sedation? Dopamine suppose to be a stimulating neurotransmitter, thus its agonists should cause stimulation instead! (I don't doubt it, of course)
> Could someone with knowledge in psychopharmacy help me to understand this?I don't know all that much, but, that said, many neurotransmitters, dopamine included, have many targets in your nervous system. It may be that the D2 and D3 receptors these agonists hit merely have nothing to do with energy and etc.
Besides the reasons , i.e. lack of an FDA indication, expensiveness, that people have offered already, I have read that many people who take dopamine agonists find the side-effects excessive. This was certainly the case for me, as requip made me very tired, among a host of other annoying effects.
I would also suggest that saying that these ideas about dopamine being responsible for pleasure, energy, etc, are at best an inaccurate simplification of the way the brain works, and, some researchers believe, an error.
poster:psychobot5000
thread:791344
URL: http://www.dr-bob.org/babble/20071019/msgs/791578.html