Posted by Anonymoose on December 6, 2007, at 1:33:31
In reply to Re: Here's one!, posted by florence on December 6, 2007, at 0:58:14
Hm, selective D2Sh autoreceptor antagonism sounds enticing. It would be nice to be able to not have to rely on Mirapex over the long run, but I'd need something to kickstart my dopamine synthesis into gear. I think I have low levels of dopamine synthesis since Deprenyl has only a minor effect on me, yet Mirapex ("synthetic dopamine") is already giving me around 80% symptomatic remission.
If you're right about Mirapex lowering DA synthesis/release through its binding at D2Lh, that's a bit bothersome. Hopefully the low-dose Deprenyl can keep enough of the precious DA around long enough to replenish vesicular stores through DAT reuptake over time.
5HT+ and NE+ drugs were no good for me either. I suspect neither are any good for someone with already normal 5HT and NE levels. The 5HT+ meds did nothing for me but increase apathy, and the NE+ meds did nothing other than make me really jumpy and send my blood pressure through the roof.
It's too bad Solian's not avail in the US. Are there any others w/similar action? Maybe Zyprexa exhibits D2Sh antagonism, too. I haven't been able to find much solid info on it, other than it possibly exhibits antagonistic effects at 5HT-2 and DA receptors.
Mirapex and Requip are pretty similar in their affinities, right? Which one has a lower affinity for D2Lh?
poster:Anonymoose
thread:797625
URL: http://www.dr-bob.org/babble/20071204/msgs/799050.html