Re: Here's one!

Posted by Anonymoose on December 6, 2007, at 3:09:59

In reply to Re: Here's one! » florence, posted by Anonymoose on December 6, 2007, at 1:33:31

Actually, I couldn't resist looking it up myself. From the PDSP Database:
RECEPTOR | TEST LIGAND | K(i)
-----------------------------
D2Sh Pramipexole 954.992586
D2Sh Ropinirole 676.082975
D2L Pramipexole 1,698.243652
D2L Ropinirole 933.254301
D3 Pramipexole 10.471285
D3 Ropinirole 37.153523
All values taken from the same study: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12388666&dopt=AbstractPlus
So, if I'm reading this right, it looks like Pramipexole has a weaker affinity for D2Sh/L, but a stronger affinity for D3.
Oh wow, it looks like Amisulpride is a really strong D2/D3 antagonist:
RECEPTOR | TEST LIGAND | K(i)
-----------------------------
D2 Amisulpride 1.300000
D3 Amisulpride 2.400000
I wonder how the mood-brightening effects show through the D-receptor antagonism, though. Wouldn't the extra dopamine still have to compete with the Amisulpride for binding at the necessary receptor sites to improve mood/motivation? Confused.

Thread

dopamine agonists?? B2chica 11/29/07
...
Re: dopamine agonists?? mikez 11/30/07
Re: dopamine agonists?? FOUND B2chica 11/30/07
Re: dopamine agonists?? » mikez Phillipa 11/30/07
Re: dopamine agonists?? banga 12/1/07
Re: dopamine agonists?? anonymoose 12/1/07
Re: dopamine agonists?? » anonymoose Phillipa 12/1/07
Re: dopamine agonists?? kingcolon 12/2/07
Re: dopamine agonists?? strugglingsteve 12/3/07
Re: dopamine agonists?? » strugglingsteve Phillipa 12/3/07
Re: dopamine agonists?? Ledgekay 12/4/07
Re: Here's one! florence 12/6/07
Re: Here's one! » florence Anonymoose 12/6/07
Re: Here's one! Anonymoose 12/6/07
Re: Here's one! ))Anonymoose florence 12/6/07

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