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Re: pdoc says: pristiq a bust » floatingbridge

Posted by SLS on August 29, 2009, at 12:14:21

In reply to Re: pdoc says: pristiq a bust » SLS, posted by floatingbridge on August 29, 2009, at 11:41:58

> O.K. Scott, so NARI is different from snri

Actually, "SNRI" was originally used to mean "selective norepinephrine reuptake inhibitor". However, its usage changed over time to mean "serotonin norepinephrine reuptake inhibitor". I think the acronym "NARI" was was coined in Britain.

I read in the Strattera literature last night about 'discontinuation syndrome' and I though, instantly, it will be as bad as effexor or (we'll see) pristiq. But if it's a different class, maybe not?

I don't think the withdrawal syndrome from discontinuing Strattera is particularly bad, and should be much more tolerable compared to Effexor. Personally, I don't remember having any withdrawal symptoms from Strattera.

Wellbutrin is a unique drug whose mechanism of action is still being debated. I think there is a growing opinion that it is a reuptake inhibitor of dopamine and norepinephrine. I'm not convinced. I do think that it does influence NE neurotransmission, I'm just not sure how. Wellbutrin has some effectiveness in treating ADD, but not as much as Strattera.


- Scott

 

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