Posted by Larry Hoover on September 9, 2004, at 10:33:51
In reply to Re: Supplements for brain fog? » KaraS, posted by raybakes on September 5, 2004, at 13:19:05
> TMG and B12 are both excellent, but the B12 from intensive nutrition works best - other B12s have made me feel awful!
This sort of thing mystifies me. I feel awful with some brands of B12, as well. I wish I had access to chromatography equipment. I'd like to get to the bottom of this.
> Tried DLPA a couple of years ago and felt like my head was going to explode! But in the last few weeks since I've been taking norival (n-acetyl tyrosine and biopterin that you mention) and niacinamide, I now feel on top of the world if I take DLPA. I wonder if the niacinamide and biopterin are helping phenylalanine hydroxylase so I can now metabolise l-phenylalanine?
I suppose that's a possible explanation.
> This abstract looks interesting, and might explain why I felt so awful with the phenylalanine initially - it might have been blocking my tyrosine and tryptophan transport into my neurons?
That effect is partially mediated by low blood insulin. If you're hyperglycemic.....
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3540926&dopt=Abstract
The phenylalanine hydroxylase deficiency syndrome is also know as PKU. I have never heard of an acquired form of PKU. <shrug>
> Have taken tyrosine before, and felt nothing, n-acetyl tyrosine and biopterin feels great though. Might try Jarrow's n-acetyl tyrosine without biopterin to feel the difference, unless anyone know's where you can get biopterin alone.
>
> I know foilc acid and biopterin are related and share activating enzymes (methyl tetrahydrobiopterin and methyl tetrahydrofolate use the same enzyme I think) but I'm not sure if there's any overlap in their function - it doesn't seem to feel that way when I've experimented.Folate is a pro-cofactor. Folate is inactive. It is modified by various enzymes to produce activated forms, including biopterins and MTHF. Defects in the activating enzymes lead to functional defects in folate metabolism which are not ameliorated by folate supplementation.
> So now I feel excellent when I take DLPA and I hope it stays that way, as I know from experience that crashes are never far away! I've heard that D-phenylalanine blocks the degradation of endorphins - I took some mistletoe tincture, also claimed to boost endorphins, and got a similar feeling too - although, too much and I got that 'wired/hyper' feeling. What I find with the DLPA is that parts of my brain 'light up', and pain in my abdominal area reduces. Also my skin feels more tingly, alive and sensitive, but none of that happened when I took it before!Hmmmm.....I'll be think about this.....
> PARP (poly ADPribose polymerase) seems to be important to me too, the DNA repair enzyme triggered by superoxide/peroxynitrite. Hopefully the niacinamide reduces it's energy sapping effect - but I also do well on other peroxynitrite/superoxide quenchers such as blueberries, grape seed and do very well on the herbs in venocap by thorne research - maybe venocap protects blood vessels by, in part, inhibiting the free radicals that trigger PARP? There's quite a few abstracts on PARP and it's involvement in blood vessel and neural dysfuntion in diabetes.I see no mention of selenium. It's a pretty important part of quenching this free-radical cascade.
> Also had great smokies immune genetic profile done, and I have a polymorphisms in my interleukin 1 receptor antagonist gene! It means that I'm prone to chronic inflammation from unopposed expression of interleukin 1 - seems people with autoimmune disease frequently have this polymorphism. High levels of interleukin 1 can trigger free radical production and all the mitochondrial problems mentioned before.I'm really glad you have pointed this out. Sometimes I just forget some key issues, and this is clearly one of those.
> Sorry, I'm going on a bit! Not much more to go! Do well on thorne's st john's wort (hyper-ex), especially if I've eaten too many oranges. Think my cyp3A4 enzyme can be low sometimes, does it work on hydroxylase enzymes too?Not that I'm aware of. It does induce p-glycoprotein.....oh, as you say....
> Interested that it also increases p-glycoprotein, and so helps with glutathione transport across cell membranes (and other conjugates too). For infection, I do well with lactoferrin, medium chain triglycerides and citricidin.....phew, hope you're not overwhelmed or bored!
>
> RayKeep talking, dude.
Lar
poster:Larry Hoover
thread:359642
URL: http://www.dr-bob.org/babble/alter/20040901/msgs/388665.html