Posted by raybakes on September 10, 2004, at 5:02:56
In reply to Re: Supplements for brain fog? » raybakes, posted by Larry Hoover on September 9, 2004, at 10:33:51
Hi Larry, I've looked up a bit more about biotpterin, thought you might be interested...
>The phenylalanine hydroxylase deficiency syndrome is also know as PKU. I have never heard of an acquired form of PKU. <shrug>I think I may have a reduced function of phenylalanine hydroxylase, that may behave like PKU when I'm low in the co-factors like biopterin and NADPH - here's some abstracts that may explain..
Depression and biopterin
Mental illness in mild PKU responds to biopterin
http://www.bh4.org/pdf/koch.pdfBiopterin responsive phenylalanine hydroxylase deficiency.
>Folate is a pro-cofactor. Folate is inactive. It is modified by various enzymes to produce activated forms, including biopterins and MTHF. Defects in the activating enzymes lead to functional defects in folate metabolism which are not ameliorated by folate supplementation.Not sure about folate being a substrate for biopterin - I heard several people say it is, but some articles say it's synthesized from GTP....
'An enzyme (dihydrobiopterin synthetase), involved in the synthesis of pterins from GTP has been implicated in this disorder (see Fig. 3). [Note that, in contrast to similar coenzymes (flavins and folates), biopterin can be synthesized by humans and is, therefore, not derived from a vitamin.]'
>I see no mention of selenium. It's a pretty important part of quenching this free-radical cascade.
I do take selenium in thiodox from allergy research - it has both riboflavin and selenium to help reduce glutathione - I don't seem to do that well with selenium alone.
Thanks,
Ray
poster:raybakes
thread:359642
URL: http://www.dr-bob.org/babble/alter/20040901/msgs/389087.html