Posted by Larry Hoover on October 31, 2004, at 8:41:43
In reply to Re: Bowel toxins,enzyme peptide conversion of aminos? » Larry Hoover, posted by raybakes on October 31, 2004, at 7:33:52
> Hi Lar, it was the link with breast cancer and beta glucuronidase that got me thinking about recirculation of deconjugated toxins. In alternative medicine review, it claims the build up of glucuronidase in the gut allows estrogens to recirculate
Possibly, but the total circulating estrogen concentration is dependent, via feedback regulation, on the integrated estrogen level itself. Real-time estrogen concentration sampling regulates estrogen production; it is not relevant whether the sampled estrogen is de novo or recycled. If "unnatural" estrogen is an issue, what about the profound influence of exogenous estrogen from birth control or hormone replacement therapy?
> and increase cancer risk in estrogen sensitive tissue - so I think recirculation of toxins is a factor in the effects of bowel flora imbalances.
I think we may have a forest and trees problem again. Beta-glucoronidase is a lysosomal enzyme. It is active everywhere in the body, because it is a necessary component of cleanup operations following apoptosis, for example.
It is found in high concentrations in one genus of gut flora, the eschericia. E. coli contamination of food, for example, is rapidly determined by tests for beta-glucoronidase.
Defects in the production of beta-glucoronidase can be fatal.
http://www.mult-sclerosis.org/news/Nov2002/GeneTherapyWorksLate.html
> Calcium-D-glucarate.
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> Calcium-D-glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by mammals, including humans. Glucaric acid is also found in many fruits and vegetables with the highest concentrations to be found in oranges, apples, grapefruit, and cruciferous vegetables. Oral supplementation of calcium-D-glucarate has been shown to inhibit beta-glucuronidase, an enzyme produced by colonic microflora and involved in Phase II liver detoxification. Elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers. Other potential clinical applications of oral calcium-D-glucarate include regulation of estrogen metabolism and as a lipid-lowering agent
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> rayI just don't know if messing with this enzyme is indicated, absent some sort of health problem, such as hormone-dependent cancer.
Lar
poster:Larry Hoover
thread:407758
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/409491.html