Posted by Larry Hoover on November 2, 2004, at 11:37:57
In reply to Re: Bowel toxins,enzyme peptide conversion of aminos? » Larry Hoover, posted by raybakes on November 1, 2004, at 7:38:03
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> > A sulphotransferase is the enzyme which conjugates, via sulphonation, some substrate. That targets it for excretion, while at the same time, blocking its metabolic activity.
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> > The corollary deconjugating enzyme is a sulphonase.
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> Hi Lar, the articles I've been reading call the deconjugating enzyme sulfatase/sulphatase?The nomenclature gets confusing, doesn't it? The American spelling of sulphur is sulfur, and now it looks like the f is winning out over the ph.
Oh, geez, maybe I read something more into the nomenclature than was intended. Sulphotransferases may sulphonate, or they may sulphate, apparently. It may mean they are non-specific, or it may mean the nomenclature is nonspecific. Hmmmm.
A sulphonase has to be different than a sulphatase, though, as the designated substrate is different.
A sulphoxide has one oxygen double bonded to sulphur. An example is DMSO (dimethyl sulphoxide; methyl- S=O -methyl). An example of a sulphonyl sulphur is MSM, methyl-sulphonyl-methane. It has a two oxygen atoms, double-bonded to sulphur (methyl- O=S=0 -methyl). A sulphonate sulphur has three oxygens, but a single bond to the organic substrate. A sulphate sulphur is sulphur bound to four oxygens, and is bound to the organic substrate by an oxygen bridge.
In any case, I didn't mean to suggest that there aren't multiple conjugating and deconjugating enzymes. The terminology (nomenclature) also leaves a lot to be desired.
There is a possible "logic" to having a nonspecific conjugating enzyme (sulphotransferase) and specific deconjugating ones, though. I just don't know where the truth lies, here.
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> Found this abstract interesting - infection/inflammation can decrease the availability of sulphate but upto 80%
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> Autism And Sulphation: The Role Of Cytokines
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> As sulphate is required for the synthesis of gut mucins and the functioning of the digestive system, infections or inflammatory responses would depress the body’s capacity to break proteins down to amino-acids, resulting in higher levels of peptides, and would also lead to ‘leaky gut ‘syndrome.
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> http://www.mindofachildaustralia.org/abstract-waring.htmlHmmmm. I need to process this bit.
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> > I just want to say that most of the drug interactions that people get concerned about actually take place in the wall of the intestine....at least those which have immediate
> effect.
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> if the drugs are reacting with dextoxification enzymes in the gut, doesn't this have implications for the whole body, and the brain?I'm not sure where you're going with that. The primary reason that the enzymes act in the gut wall is driven by evolution. Not all foods are fully non-toxic, but they may still be nutritive. What was not anticipated by evolution was the profound change in diet caused by agriculture.
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> > My central point, hitherto unexpressed, is that there is a lot more to "hepatic" enzymes than meets the eye. We're only just starting to understand the complexity of interactions. Rather than trying to affect a specific aspect of e.g. hepatic function, it makes more sense to promote hepatic health. Unless, of course, a specific disorder is being considered.
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> I still feel that a toxic bowel will overload detoxification enzymes in the bowel and put more of a load on detoxification elsewhere in the body - including the brain. Do you not feel that is possible?Sure, that's a plausible mechanism for what we're talking about, although "toxic bowel" leaves me a little ambivalent.
> Thanks for the debate/chat/information - hope it's not getting too heavy!
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> RayIf it is, I'll just disappear again. That's an unconscious coping strategy. I just do what I gotta do, or don't what I gotta don't.
Lar
poster:Larry Hoover
thread:407758
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/410585.html