Posted by raybakes on November 7, 2004, at 5:06:24
In reply to Re: dopamine oxidation » raybakes, posted by Larry Hoover on November 4, 2004, at 11:02:03
> The ascorbyl radical can then participate in chain reactions, but it is less reactive than the originating free radical. Glutathione quenches the ascorbyl radical, but is itself now a radical. There are a few processes by which glutathione is regenerated, and one of those is via alphalipoic acid.
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Hi Lar,I can only tell you what if feels like - I think high dose ascorbate would be fine with someone with normal health. I know if I take over 1 gramme of magensium ascorbate, I feel incredibly ill, mentally.
I understand the outline that you give about how all the antioxidant systems working in concert produce radicals or become radicals in the process of dealing with a free radical, but matching how I feel to what you say, there must be something else going on. I feel my antioxidant system is extremely fragile, and can probably only work at a certain rate - It probably has a few weak links in the chain - enzymes that when pushed too hard, run out of co-factors (NADPH to reduce glutathione is a suspect, particularly because it requires energy, something my brain lacks!).
So ascorbate could produce more ascorbyl radicals than glutathione could mop up before I started running low on NADPH. With NADPH running low, hydrogen ions build up in the cell, the pH drops, all enzymes fail, and I end up with millions more free radicals that I started with!
Just a theory, but that's how it sort of feels!
Ray
poster:raybakes
thread:404137
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/412776.html