Posted by tealady on November 14, 2004, at 4:04:46
In reply to Re: dopamine oxidation » raybakes, posted by Larry Hoover on November 7, 2004, at 11:07:11
OK guys I'm back, exams over and feeling much better
> > > The ascorbyl radical can then participate in chain reactions, but it is less reactive than the originating free radical. Glutathione quenches the ascorbyl radical, but is itself now a radical. There are a few processes by which glutathione is regenerated, and one of those is via alphalipoic acid.
> > >
> > >
> > Hi Lar,
> >
> > I can only tell you what if feels like - I think high dose ascorbate would be fine with someone with normal health. I know if I take over 1 gramme of magensium ascorbate, I feel incredibly ill, mentally.Ray
Magnesium ascorbate is what I usually take too..and I do best with under 1 gram as well. I uually don't take it daily for this reason...just what is in my multi...and fruit
>
> Maybe that's the magnesium "talking"?
>
> > I understand the outline that you give about how all the antioxidant systems working in concert produce radicals or become radicals in the process of dealing with a free radical, but matching how I feel to what you say, there must be something else going on.
>With me too Ray. I agree.
> I looked at the toxicity of vitamin C, and two possible mechanisms come to mind. One involves iron toxicity, exacerbated by the activation by ascorbate. Those with hemochromatosis are particularly vulnerable to this effect. The other mechanism involves enhanced excretion of uric acid. That might leave one vulnerable to peroxynitrite, as uric acid is an excellent peroxynitrite scavenger.
>
I think I have a problem with peroxynitrate (amongst other things).
Lar,
In your opinion if one produce a lot of urine(say 6L a day) and it seemed to be produced faster than would be expected (I guess this happens as I always have problems with ultrasounds:) is that what you mean by enhanced excretion of uric acid??> > I feel my antioxidant system is extremely fragile, and can probably only work at a certain rate - It probably has a few weak links in the chain - enzymes that when pushed too hard, run out of co-factors (NADPH to reduce glutathione is a suspect, particularly because it requires energy, something my brain lacks!).
>
Yes I'm the same and gluthathione from reading your posts is something I think I lack too. Still trying to learn about.
BTW where did you get that list of glutahione foods..if you have a link easily located that is.>
> > So ascorbate could produce more ascorbyl radicals than glutathione could mop up before I started running low on NADPH.
Maybe that is what happens to me as well>With NADPH running low, hydrogen ions build up in the cell, the pH drops, all enzymes fail, and I end up with millions more free radicals that I started with!
Hmm I don't think it works like that, hydrogen ions are after NADH is made..in the chemiosmosis the next stage..and the NADH has its electrons passed along the mitochondrial membrane and H+ ions get pumped into the intermembrane space thru the proton pumps (NADH-ubiquinone oxidoreductase, then ubiquinone-cytochrome c oxidoreductase, then cytochrome c oxidase) .. and in the last one Oxygen is consumed and water formed...or something like that
I keep thiking its my dumb oxygen as I still run short on it..or feel like it sometimes..that's when I get real depressed , and sometimes my circulation in my extremities kinda shuts down, I go cold and hands turn blueish etc and numb
>
> I really doubt there's a pH mechanism at play. There are many many ways for cells to adjust pH. There are substantial buffer systems in place, just for that purpose. Do you understand the chemistry of buffer systems?
>Umm Lar I have high Cl-(topmof range) and low bicarbonate ions(bottom of range)...so that would indicate what?? pH related??
Remember I once said I didn't get all this acid/base stuff..well I still don't really get it..the buffer sytems..but I'm beginning to grasp a little
> > Just a theory, but that's how it sort of feels!
yep..now that I understand!!
> >
> > Ray
Jan
poster:tealady
thread:404137
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/415707.html