Posted by Larry Hoover on December 10, 2004, at 9:36:50
In reply to Re: can carnitine mimic cortisol?, posted by Ktemene on November 25, 2004, at 22:38:00
> > 'L-carnitine: A nutritional modulator of glucocorticoid receptor functions.'
> >
> > "There is evidence that, at high doses, L-carnitine might mimic some of the biological activities of glucocorticoids, especially immunomodulation."
> >
> >
> > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12824292
>
> Hi Ray,
>
> Thanks for the reference. I read the article but I am too ignorant to understand it. If you have time, could you explain what would it mean for us if L-carnitine can mimic cortisol?
>
> KtemeneL-carnitine is a direct agonist at glucocorticoid receptors, but concentration is important here. If the dose is high enough, it acts like cortisol.
The full-text article says they're talking about doses as high as 600mg/kg body weight. For a seventy kilogram (about 150 lb.) adult, that's over 40 grams a day.
Health Canada prohibits the importation of l-carnitine into Canada, as far as I know, so the issue is moot for me.
Lar
poster:Larry Hoover
thread:419010
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/427155.html