Posted by jujube on December 11, 2004, at 8:29:05
In reply to Re: can carnitine mimic cortisol? » Ktemene, posted by Larry Hoover on December 10, 2004, at 9:36:50
> > > 'L-carnitine: A nutritional modulator of glucocorticoid receptor functions.'
> > >
> > > "There is evidence that, at high doses, L-carnitine might mimic some of the biological activities of glucocorticoids, especially immunomodulation."
> > >
> > >
> > > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12824292
> >
> > Hi Ray,
> >
> > Thanks for the reference. I read the article but I am too ignorant to understand it. If you have time, could you explain what would it mean for us if L-carnitine can mimic cortisol?
> >
> > Ktemene
>
> L-carnitine is a direct agonist at glucocorticoid receptors, but concentration is important here. If the dose is high enough, it acts like cortisol.
>
> The full-text article says they're talking about doses as high as 600mg/kg body weight. For a seventy kilogram (about 150 lb.) adult, that's over 40 grams a day.
>
> Health Canada prohibits the importation of l-carnitine into Canada, as far as I know, so the issue is moot for me.
>
> LarLarry,
FYI. I have found a place in Canada where I can get Acetyl L-Carntine. If ever you decide you want to try some, I will get you the contact number.
Tamara
>
poster:jujube
thread:419010
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/427696.html