Posted by Mistermindmasta on December 10, 2004, at 22:33:13
In reply to The high maintenance regimen of l-tryp??, posted by cherylann on December 10, 2004, at 11:34:04
> I want to make sure I get this right. L-tryptophan needs to be taken on an empty stomach with b6 and niacin at the same time.
>Theoretically, this would help since niacin and B6 are necessary for serotonin production, but I might assume that its not necessary for B6 and Niacin to be taken at the same time as the L-tryp.
> I also understand you shouldn't eat any kind of protein within a couple hours, correct?If you have other amino acids competing for uptake into the brain, the l-tryp will not work as well, if at all.
>
> If l-tryp is sedating, do I take it in the evening? I can't seem to find this info on the healthrecovery site.
>I've taken 5-HTP (which is one step closer to serotonin) during the day and find that it doesnt sedate me or make me sleepy, but it makes me a little bit spacy. Its actually kind of a strange feeling - I feel a bit stimulated but dumbed down too.
> I'll also need to add l-tyrosine for the norepinephrine, which I think I'm low on. Hopefully the l-tryp IS sedating, because I understand the l-tyrosine is quite activating.
>If you have physical anxiety or ADHD with your depression, its likely that your norepinephrine and / or epinephrine levels are a bit high, at least in some parts of the brain. You don't really need to raise NE levels in this case. If your depression is mainly emotional but your anxiety is low, then you might be low in norepinephrine. In any case, I have the belief that l-tyrosine has its stimulating effects by increasing dopamine in the prefrontal cortex, not by its effects on norepinephrine. This is based on my personal observations and a few studies. Tyrosine will increase norepinephrine if it is low from stress (i.e. tyrosine depletion) or drug use, but I don't think it will increase it above your baseline level. Studies show that tyrosine supplementation does not elevate norepinephrine levels. Studies in rats also show chronic increases in dopamine from tyrosine supplementation. Generally speaking, increasing norepinephrine nonspecifically will increase blood pressure; l-tyrosine sometimes lowers it. I'm not sure how this works. One study says its from stimulation of the alpha adrenergic receptors which causes negative feedback thus lowering NE. It seems rather confusing indeed! But I'd say that stimulating effect you're going for is actually from an increase in dopamine, which tyrosine will provide.
It's not stimulating like a cup of coffee is. It's a little bit smoother for me. What I've done is take 5-HTP, then a few hours later eat a meal, then a few hours later take tyrosine, in a cycle like that. That seems to do a nice job of stimulating and relaxing me. Unfortunately, this combo seems to lose effectiveness after several days of continous use.
> It would be nice if what this combo creates is as close to a natural TCA as I can get, as that's the only drug I respond well to.
>
> Lord, I hope this combo works. The remeron I'm taking is causing bad leg pain, which I thought was cuz I was just chubby. AND, I'm getting the flu like symptoms every week. Scary.
>
> Thanks
> cherylannIt might work for you. I especially dislike the GI effects, though. Tyrosine or HTP alone give me the runs, let alone combined. This effect SEEMS to lessen after a few days, but I havent continued this program long enough to see for definite if it completely goes away.
poster:Mistermindmasta
thread:427216
URL: http://www.dr-bob.org/babble/alter/20041123/msgs/427517.html