Posted by KaraS on April 17, 2005, at 2:45:02
In reply to Re: KaraS, another question for you » KaraS, posted by Sarah T. on April 16, 2005, at 23:16:18
> KS:>> I was thinking in terms of mixing Surmontil (or doxepin?) with selegiline + DLPA. I had been waiting for the Ensam patch but since I had the anxiety meltdown a couple of months ago, I'm afraid I wouldn't be able to tolerate the patch unless I'm able to combine it with something very anxiolytic. (Initially when I tried selegiline it made me sleepy but after the third or fourth day, it still made me feel tired initially but started producing more of a stimulant type effect about 8-9 hours after I took it.) But maybe you're right, maybe the transdermal delivery system will reduce the side effects and make it easier to tolerate for both of us. Then maybe they'll make a lot of psych meds in patch form and life will get much easier for many of us. (I'm trying to think positively, can you tell?) > Kara >
>
> ST: I wonder why you got tired from the Selegiline at first. How many milligrams did you take? When you felt the stimulant effect 8-9 hours later, perhaps it was one or more of those metabolites kicking in. I am curious about your initial fatigue on what is supposedly a stimulating medicine. One reason for my interest is that, when I developed tolerance to Dexedrine, that tolerance manifested primarily as fatigue (sometimes extreme) and, at times, a zombie-like affect. I assumed that my presynaptic receptors had become overly efficient at dopamine reuptake. Initially, my doctor told me to take more, but that was the worst thing to do! I became completely immobilized when I increased the daily dose, or if I took too many milligrams at once, or if I took one dose too close to the next one.I think I may have hypersensitive dopamine autoreceptors (not caused by stimulants in my case). I have reacted paradoxically to other stimulating meds and supplements. Things that are supposed to make me quite stimulated usually put me to sleep instead. The fact that after a few days I was getting stimulation 8-9 hours later was actually quite a good sign for me. Your experience with Dexedrine sounds terrible. It sounds like you've had some really bad experiences with a lot of medications. I hope that doxepin or Surmontil will help you without providing any new problems.
K
poster:KaraS
thread:478017
URL: http://www.dr-bob.org/babble/alter/20050414/msgs/485365.html