Posted by Chairman_MAO on May 8, 2005, at 21:32:19
In reply to Re: PEA -- where to find... » Chairman_MAO, posted by JLx on May 8, 2005, at 11:25:55
I injected the PEA IV to see if there was a difference in effect if I got past any possible first-pass liver metabolism, not to get high, as I had ingested it orally before and knew that it certainly didn't get you high. ;)
I am so glad that I am on medication that fixes whatever is wrong up there so that I don't feel driven to conduct such experiments out of desparation to feel better.
Without an MAOI, you will not feel any PEA you take externally, because it will be broken down by MAO-B before it has a chance to do anything. When I meant "work up", I meant "increase as necessary", and forgot to mention the maximum (as used in the study I read) was somewhere around 60mg.
I don't like the idea of taking DLPA to get PEA. There are just too many other things that it metabolizes into; for me, at least, it was even more agitating than taking 10mg of PEA daily in the long run.
Exercise is connected a lot more to the endogenous opioid system than it is to PEA. Chocolate consumption, due to the sugars (and maybe fats, I'm not totally clear), increases endorphin secretion. The "high" from chocolate, IIRC, has more to do with the opioid side of things than it does with PEA, despite the fact that PEA is in chocolate. I may be wrong on this, but if I am I'd like to see the references so I can get up to speed.
Also, increased sugar consumption and the subsequent insulin release alters the permeability of the BBB to allow more l-tryptophan (I think) across, thereby increasing 5HT synthesis and providing a calm, satisfied feeling. That is another mechanism of choco-happiness. ;)
poster:Chairman_MAO
thread:488304
URL: http://www.dr-bob.org/babble/alter/20050414/msgs/495365.html